Precise genome editing with base editors

Abstract: Single-nucleotide variants account for about half of known pathogenic genetic variants in human. Genome editing strategies by reversing pathogenic point mutations with minimum side effects have great therapeutic potential and are now being actively pursued. The emerge of precise and efficient genome editing strategies such as base editing and prime editing provide powerful tools for nucleotide conversion without inducing double-stranded DNA breaks (DSBs), which have shown great potential for curing genetic disorders. A diverse toolkit of base editors has been developed to improve the editing efficiency and accuracy in different context of application. Here, we summarized the evolving of base editors (BEs), their limitations and future perspective of base editing-based therapeutic strategies.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Precise genome editing with base editors ; volume:3 ; number:1 ; year:2023 ; pages:75-84 ; extent:10 ; Medical Review ; 3, Heft 1 (2023), 75-84 (gesamt 10)

Contributors, Places and Time

• Creator: Liu, Hongcai ; Zhu, Yao ; Li, Minjie ; Gu, Zhimin

Further information

• DOI: 10.1515/mr-2022-0044
• URN: urn:nbn:de:101:1-2023033114035724484853
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 14.08.2025, 10:58 AM CEST