Protective effect of Lactobacillus -containing probiotics on intestinal mucosa of rats experiencing traumatic hemorrhagic shock
Abstract: This study was conducted to assess whether Lactobacillus-containing probiotics could protect intestinal mucosa in rats during traumatic hemorrhagic shock and to determine its underlying mechanisms. Healthy male Sprague–Dawley rats (300 ± 20 g) were randomly divided into four groups. During the study, reverse transcription polymerase chain reaction, western blotting, and hematoxylin and eosin methods were used. There was a significant increase in the expression of toll-like receptor 4 (TLR4) in the rats that experienced traumatic hemorrhagic shock, along with increased mRNA of tumor necrosis factor-alpha (TNF-α) and interleukin (IL)-6. Pretreatment with Lactobacillus-containing probiotics reduced TLR4 expression, decreased phosphorylation (Ser536) and acetylation (Lys310) of p65, and decreased TNF-α and IL-6 mRNA. The probiotics combined acetate Ringer’s group showed a less severe pathological manifestation compared to the other experimental groups. Lactobacillus-containing probiotics inhibited nuclear factor-kappa B signaling via the downregulation of TLR4, resulting in inflammatory homeostasis, which might be the mechanism whereby Lactobacillus protects the intestinal mucosa from damage caused by the traumatic hemorrhagic shock.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Protective effect of Lactobacillus -containing probiotics on intestinal mucosa of rats experiencing traumatic hemorrhagic shock ; volume:16 ; number:1 ; year:2021 ; pages:1122-1129 ; extent:8
Open life sciences ; 16, Heft 1 (2021), 1122-1129 (gesamt 8)
- Creator
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Wang, Lei
Liu, Shu-li
Xu, Zhi-peng
Song, Qi
Li, Lei
Qiu, Zhao-lei
Wang, Zhen-jie
- DOI
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10.1515/biol-2021-0112
- URN
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urn:nbn:de:101:1-2022091914575978272701
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:29 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Wang, Lei
- Liu, Shu-li
- Xu, Zhi-peng
- Song, Qi
- Li, Lei
- Qiu, Zhao-lei
- Wang, Zhen-jie
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