Hepatoprotective role of peroxisome proliferator-activated receptor-α in non-cancerous hepatic tissues following transcatheter arterial embolization

to related objects

Abstract: Transcatheter arterial embolization (TAE) is a widely used technique in treating hepatic carcinoma but may cause liver injury in some cases. This study investigated the hepatoprotective effect of the preprocessed peroxisome proliferator-activated receptor-α (PPAR-α) agonist-WY-14643 following TAE. A total of 60 rabbit liver cancer models were developed and divided into a combined treatment (WY-14643 and TAE), TAE, and control groups. After TAE, we examined the histopathological picture and liver functions. Further, the expression of antioxidant enzymes, tumor necrosis factor-α (TNF-α), nuclear factor of κ-light chain of enhancer-activated B cells (NF-κB), PPAR-α, and B-cell lymphoma-2 (Bcl-2) was analyzed. Liver function tests, pathology score, and apoptosis index significantly worsened in the TAE group but were normalized in the combined treatment group. In addition, ELISA results showed that antioxidant enzyme activity significantly increased, while the malondialdehyde content and level of inflammatory cytokines were significantly reduced in the combined treatment group. Furthermore, compared to the TAE group, the expressions of PPAR-α, antioxidant enzymes superoxide dismutase1 (SOD1) and SOD2, and Bcl-2 were significantly elevated, while NF-κB was significantly reduced in the combined treatment group. On the other hand, the expression of NF-κB in tumor tissues was significantly reduced by pretreatment with WY-14643. Therefore, PPAR-α can ameliorate liver injury by exerting its anti-oxidative, anti-inflammatory, and anti-apoptotic functions.

Location
Deutsche Nationalbibliothek Frankfurt am Main
Extent
Online-Ressource
Language
Englisch

Bibliographic citation
Hepatoprotective role of peroxisome proliferator-activated receptor-α in non-cancerous hepatic tissues following transcatheter arterial embolization ; volume:17 ; number:1 ; year:2022 ; pages:827-838 ; extent:12
Open life sciences ; 17, Heft 1 (2022), 827-838 (gesamt 12)

Creator
Yang, Peiyu
Li, Zhengliang
Du, Wei
Wu, Chunhua
Xiong, Wencui

DOI
10.1515/biol-2022-0068
URN
urn:nbn:de:101:1-2022081114183092566780
Rights
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
Last update
15.08.2025, 7:34 AM CEST

Data provider

This object is provided by:
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Show original at data provider

Associated

  • Yang, Peiyu
  • Li, Zhengliang
  • Du, Wei
  • Wu, Chunhua
  • Xiong, Wencui

Other Objects (12)

The homeodomain of Eyeless regulates cell growth and antagonizes the paired domain-dependent retinal differentiation function

The homeodomain of Eyeless regulates cell growth and antagonizes the paired domain-dependent retinal differentiation function

Subcutaneous calcinosis in a patient with anti-MDA5 positive dermatomyositis

Subcutaneous calcinosis in a patient with anti-MDA5 positive dermatomyositis

A novel implicit decision variable classification approach for high-dimensional robust multi-objective optimization in order scheduling

A novel implicit decision variable classification approach for high-dimensional robust multi-objective optimization in order scheduling

Alleviating role of ketamine in breast cancer cell-induced osteoclastogenesis and tumor bone metastasis-induced bone cancer pain through an SRC/EGR1/CST6 axis

Alleviating role of ketamine in breast cancer cell-induced osteoclastogenesis and tumor bone metastasis-induced bone cancer pain through an SRC/EGR1/CST6 axis

Rapid Evaluation and Response to Impacts on Critical End-Use Loads Following Natural Hazard-Driven Power Outages: A Modular and Responsive Geospatial Technology

Rapid Evaluation and Response to Impacts on Critical End-Use Loads Following Natural Hazard-Driven Power Outages: A Modular and Responsive Geospatial Technology

Estrogen improves vascular function via peroxisome-proliferator-activated-receptor-γ [peroxisome-proliferator-activated-receptor-gamma]

Hochschulschrift

Estrogen improves vascular function via peroxisome-proliferator-activated-receptor-γ [peroxisome-proliferator-activated-receptor-gamma]

Peroxisome proliferator-activated receptors (PPARs) und die Lymphozytenmigration

Hochschulschrift

Peroxisome proliferator-activated receptors (PPARs) und die Lymphozytenmigration

Hydrophobic pore space constituted in macroporous ZIF-8 for lipase immobilization greatly improving lipase catalytic performance in biodiesel preparation

Hydrophobic pore space constituted in macroporous ZIF-8 for lipase immobilization greatly improving lipase catalytic performance in biodiesel preparation

Comparison of anterior corneal aberrations measured by Scheimpflug and Placido Disc System for myopes

Comparison of anterior corneal aberrations measured by Scheimpflug and Placido Disc System for myopes

Optical molecular imaging for systems biology: from molecule to organism

Optical molecular imaging for systems biology: from molecule to organism

Predictors of distant metastasis in parotid acinic cell carcinoma

Predictors of distant metastasis in parotid acinic cell carcinoma

In Operando Characterization and Control over Intermittent Light Emission from Molecular Tunnel Junctions via Molecular Backbone Rigidity

In Operando Characterization and Control over Intermittent Light Emission from Molecular Tunnel Junctions via Molecular Backbone Rigidity

Related objects