Prenatal thalamic waves regulate cortical area size prior to sensory processing

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Abstract: The cerebral cortex is organized into specialized sensory areas, whose initial territory is determined by intracortical molecular determinants. Yet, sensory cortical area size appears to be fine tuned during development to respond to functional adaptations. Here we demonstrate the existence of a prenatal sub-cortical mechanism that regulates the cortical areas size in mice. This mechanism is mediated by spontaneous thalamic calcium waves that propagate among sensory-modality thalamic nuclei up to the cortex and that provide a means of communication among sensory systems. Wave pattern alterations in one nucleus lead to changes in the pattern of the remaining ones, triggering changes in thalamic gene expression and cortical area size. Thus, silencing calcium waves in the auditory thalamus induces Rorβ upregulation in a neighbouring somatosensory nucleus preluding the enlargement of the barrel-field. These findings reveal that embryonic thalamic calcium waves coordinate cortical sensory area patterning and plasticity prior to sensory information processing

Location: Deutsche Nationalbibliothek Frankfurt am Main

Extent: Online-Ressource

Language: Englisch

Notes: Nature communications. - 8 (2017) , 14172, ISSN: 2041-1723

Event: Veröffentlichung

(where): Freiburg

(who): Universität

(when): 2019

Creator: Moreno-Juan, Verónica
Filipchuk, Anton
Antón-Bolaños, Noelia
Mezzera, Cecilia
Gezelius, Henrik
Andrés, Belen
Rodríguez-Malmierca, Luis
Susín, Rafael
Schaad, Olivier
Iwasato, Takuji
Schüle, Roland
Rutlin, Michael
Nelson, Sacha
Ducret, Sebastien
Valdeolmillos, Miguel
Rijli, Filippo M.
López-Bendito, Guillermina

Contributor: Abteilung Onkologische Forschung in der Urologie

DOI: 10.1038/ncomms14172

URN: urn:nbn:de:bsz:25-freidok-1404207

Rights: Kein Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.

Last update: 14.08.2025, 10:55 AM CEST

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Moreno-Juan, Verónica
Filipchuk, Anton
Antón-Bolaños, Noelia
Mezzera, Cecilia
Gezelius, Henrik
Andrés, Belen
Rodríguez-Malmierca, Luis
Susín, Rafael
Schaad, Olivier
Iwasato, Takuji
Schüle, Roland
Rutlin, Michael
Nelson, Sacha
Ducret, Sebastien
Valdeolmillos, Miguel
Rijli, Filippo M.
López-Bendito, Guillermina
Abteilung Onkologische Forschung in der Urologie
Universität

Time of origin

2019

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Prenatal thalamic waves regulate cortical area size prior to sensory processing

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Other Objects (12)

Thalamic Bursts Down-regulate Cortical Theta and Nociceptive Behavior

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Supralinear reliability of cortical spiking from synchronous thalamic inputs

Basal ganglia and cortical control of thalamic rebound spikes

Primary Somatosensory Cortical Outputs Bidirectionally Modulate Nociceptive Perception, Cortical Excitability, and Thalamic Firing Mode

Thalamic and cortical contributions to physiological brain rhythms in vivo

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Synchrony in thalamic inputs enhances propagation of activity through cortical layers

Thalamic deep brain stimulation for tourette syndrome increases cortical beta activity

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Vision for action: thalamic and cortical inputs to the macaque superior parietal lobule

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