Multimodal profiling reveals site-specific adaptation and tissue residency hallmarks of γδ T cells across organs in mice : = Multimodal profiling reveals site-specific adaptation and tissue residency hallmarks of [gamma][delta] T cells across organs in mice

Abstract: γδ T cells perform heterogeneous functions in homeostasis and disease across tissues. However, it is unclear whether these roles correspond to distinct γδ subsets or to a homogeneous population of cells exerting context-dependent functions. Here, by cross-organ multimodal single-cell profiling, we reveal that various mouse tissues harbor unique site-adapted γδ subsets. Epidermal and intestinal intraepithelial γδ T cells are transcriptionally homogeneous and exhibit epigenetic hallmarks of functional diversity. Through parabiosis experiments, we uncovered cellular states associated with cytotoxicity, innate-like rapid interferon-γ production and tissue repair functions displaying tissue residency hallmarks. Notably, our observations add nuance to the link between interleukin-17-producing γδ T cells and tissue residency. Moreover, transcriptional programs associated with tissue-resident γδ T cells are analogous to those of CD8+ tissue-resident memory T cells. Altogether, this study provides a multimodal landscape of tissue-adapted γδ T cells, revealing heterogeneity, lineage relationships and their tissue residency program

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• Weitere Titel: Multimodal profiling reveals site-specific adaptation and tissue residency hallmarks of [gamma][delta] T cells across organs in mice
• Standort: Deutsche Nationalbibliothek Frankfurt am Main
• Umfang: Online-Ressource
• Sprache: Englisch
• Anmerkungen: Nature immunology. - 25, 2 (2024) , 343-356, ISSN: 1529-2916

Beteiligte, Orts- und Zeitangaben

• Ereignis: Veröffentlichung
• (wo): Freiburg
• (wer): Universität
• (wann): 2024
• Urheber: Du Halgouet, Anastasia ; Bruder, Kerstin ; Peltokangas, Nina ; Darbois, Aurélie ; Obwegs, David ; Salou, Marion ; Thimme, Robert ; Hofmann, Maike ; Lantz, Olivier ; Sagar

Weitere Informationen

• DOI: 10.1038/s41590-023-01710-y
• URN: urn:nbn:de:bsz:25-freidok-2433678
• Rechteinformation: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.