Enzymatic Synthesis of Variediene Analogs
Abstract: Five analogs of dimethylallyl diphosphate (DMAPP) with additional or shifted Me groups were converted with isopentenyl diphosphate (IPP) and the fungal variediene synthase from Aspergillus brasiliensis (AbVS). These enzymatic reactions resulted in the formation of several new terpene analogs that were isolated and structurally characterised by NMR spectroscopy. Several DMAPP analogs showed a changed reactivity giving access to compounds with unusual skeletons. Their formation is mechanistically rationalised and the absolute configurations of all obtained compounds were determined through a stereoselective deuteration strategy, revealing absolute configurations that are analogous to that of the natural enzyme product variediene.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Enzymatic Synthesis of Variediene Analogs ; day:09 ; month:02 ; year:2022 ; extent:1
Chemistry - a European journal ; (09.02.2022) (gesamt 1)
- Urheber
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Liang, Lin‐Fu
Dickschat, Jeroen S.
- DOI
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10.1002/chem.202200095
- URN
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urn:nbn:de:101:1-2022021014111020914435
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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15.08.2025, 07:25 MESZ
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Liang, Lin‐Fu
- Dickschat, Jeroen S.
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