Arginine methylation of the B cell antigen receptor promotes differentiation

Abstract: Signals processed through the B cell antigen receptor (BCR) control both the proliferation and differentiation of B lymphocytes. How these different signaling modes are established at the BCR is poorly understood. We show that a conserved arginine in the tail sequence of the Igα subunit of the BCR is methylated by the protein arginine methyltransferase 1. This modification negatively regulates the calcium and PI-3 kinase pathways of the BCR while promoting signals leading to B cell differentiation. Thus, Igα arginine methylation can play an important role in specifying the outcome of BCR signaling

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch
• Notes: Journal of Experimental Medicine. Vol. 207, no. 4 (2010), 711-719, DOI 10.1084/jem.20091303, issn: 1540-9538 ; IN COPYRIGHT http://rightsstatements.org/page/InC/1.0 rs

Classification and Topics

• Keyword: Antigenrezeptor ; Lymphozyt ; Arginin ; Methyltransferasen ; Kinasen ; Immunologie ; Immunsystem ; Leukozyt ; Immunität ; Resistenz ; Immunchemie

Contributors, Places and Time

• Event: Veröffentlichung
• (where): Freiburg
• (who): Universität
• (when): 2010
• Creator: Infantino, Simona ; Benz, Beate ; Waldmann, Tanja ; Jung, Manfred ; Schneider, Robert ; Reth, Michael
• Contributor: Albert-Ludwigs-Universität Freiburg. Centre for Biological Signalling Studies ; Albert-Ludwigs-Universität Freiburg. Institut für Pharmazeutische Wissenschaften ; Albert-Ludwigs-Universität Freiburg. Fakultät für Chemie und Pharmazie ; Albert-Ludwigs-Universität Freiburg. Fakultät für Biologie ; Max-Planck-Institut für Immunbiologie ; Albert-Ludwigs-Universität Freiburg

Further information

• DOI: 10.1084/jem.20091303
• URN: urn:nbn:de:bsz:25-freidok-130279
• Rights: Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 13.01.2027, 1:54 PM CET