Small Molecule MIF Modulation Enhances Ferroptosis by Impairing DNA Repair Mechanisms

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Abstract: Ferroptosis is a form of regulated cell death that can be modulated by small molecules and has the potential for the development of therapeutics for oncology. Although excessive lipid peroxidation is the defining hallmark of ferroptosis, DNA damage may also play a significant role. In this study, a potential mechanistic role for MIF in homologous recombination (HR) DNA repair is identified. The inhibition or genetic depletion of MIF or other HR proteins, such as breast cancer type 1 susceptibility protein (BRCA1), is demonstrated to significantly enhance the sensitivity of cells to ferroptosis. The interference with HR results in the translocation of the tumor suppressor protein p53 to the mitochondria, which in turn stimulates the production of reactive oxygen species. Taken together, the findings demonstrate that MIF‐directed small molecules enhance ferroptosis via a putative MIF‐BRCA1‐RAD51 axis in HR, which causes resistance to ferroptosis. This suggests a potential novel druggable route to enhance ferroptosis by targeted anticancer therapeutics in the future.

Location
Deutsche Nationalbibliothek Frankfurt am Main
Extent
Online-Ressource
Language
Englisch

Bibliographic citation
Small Molecule MIF Modulation Enhances Ferroptosis by Impairing DNA Repair Mechanisms ; day:25 ; month:06 ; year:2024 ; extent:15
Advanced science ; (25.06.2024) (gesamt 15)

Creator
Chen, Deng
Zhao, Chunlong
Zhang, Jianqiu
Knol, Catharina W. J.
Osipyan, Angelina
Majerníková, Nad'a
Chen, Tingting
Xiao, Zhangping
Adriana, Jeaunice
Griffith, Andrew J.
Gamez, Abel Soto
van der Wouden, Petra E.
Coppes, Robert P.
Dolga, Amalia M.
Haisma, Hidde J.
Dekker, Frank J.

DOI
10.1002/advs.202403963
URN
urn:nbn:de:101:1-2406251421133.933757008611
Rights
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
Last update
14.08.2025, 10:53 AM CEST

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Associated

  • Chen, Deng
  • Zhao, Chunlong
  • Zhang, Jianqiu
  • Knol, Catharina W. J.
  • Osipyan, Angelina
  • Majerníková, Nad'a
  • Chen, Tingting
  • Xiao, Zhangping
  • Adriana, Jeaunice
  • Griffith, Andrew J.
  • Gamez, Abel Soto
  • van der Wouden, Petra E.
  • Coppes, Robert P.
  • Dolga, Amalia M.
  • Haisma, Hidde J.
  • Dekker, Frank J.

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