The Delicate Skin of Preterm Infants: Barrier Function, Immune-Microbiome Interaction, and Clinical Implications
The skin of preterm infants is a delicate organ with critical structural and functional differences as compared to term born infants. Unique features contribute to an increased susceptibility to injury, infection, thermal instability, and water loss. During rapid, often accelerated adaption of the physical barrier function of preterm skin, a parallel and mutual development of host skin immunity and skin microbiome seem to be crucial for skin homeostasis. Recent advances in molecular biology have enabled researchers to gain a deeper understanding of the microbial community composition of preterm skin and the important relationship with microbiome composition of other body sites. Nevertheless, several questions remain to be answered, including niche factors and environmental influences on skin maturation. In line with that, evidence-based guidelines on skin care practice in preterm infants are missing. This review articles aims to provide an overview of the current knowledge of preterm infant skin development including immune and barrier function, host-microbial interactions, and potential clinical implications.
- Location
-
Deutsche Nationalbibliothek Frankfurt am Main
- Extent
-
Online-Ressource
- Language
-
Englisch
- Bibliographic citation
-
The Delicate Skin of Preterm Infants: Barrier Function, Immune-Microbiome Interaction, and Clinical Implications ; volume:120 ; number:3 ; year:2023 ; pages:295-307 ; extent:13
Neonatology ; 120, Heft 3 (2023), 295-307 (gesamt 13)
- Creator
-
Marissen, Janina
Gomez de Agüero, Mercedes
Chandorkar, Parul
Reichert, Lilith
Glaser, Kirsten
Speer, Christian P.
Härtel, Christoph
- DOI
-
10.1159/000529026
- URN
-
urn:nbn:de:101:1-2023072000185728523717
- Rights
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
-
14.08.2025, 10:57 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Marissen, Janina
- Gomez de Agüero, Mercedes
- Chandorkar, Parul
- Reichert, Lilith
- Glaser, Kirsten
- Speer, Christian P.
- Härtel, Christoph
Other Objects (12)
Vitamin D and gut microbiome in preterm infants
Meconium microbiome of very preterm infants across Germany
Dichotomous development of the gut microbiome in preterm infants
Prognosis of Full Thickness Skin Defects in Preterm Infants
Development of the preterm infant gut microbiome: a research priority
Intrauterine Inflammation, Epigenetics, and Microbiome Influences on Preterm Infant Health
Intravenous antibiotics in preterm infants have a negative effect upon microbiome development throughout preterm life
Early-life skin microbiota in hospitalized preterm and full-term infants
The impact of breastfeeding on the preterm infant’s microbiome and metabolome: a pilot study
Duration of skin-to-skin care and rectal temperatures in late preterm and term infants
Delicate attention
Delicate consideration
Vitamin D and gut microbiome in preterm infants
Meconium microbiome of very preterm infants across Germany
Dichotomous development of the gut microbiome in preterm infants
Prognosis of Full Thickness Skin Defects in Preterm Infants
Development of the preterm infant gut microbiome: a research priority
Intrauterine Inflammation, Epigenetics, and Microbiome Influences on Preterm Infant Health
Intravenous antibiotics in preterm infants have a negative effect upon microbiome development throughout preterm life
Early-life skin microbiota in hospitalized preterm and full-term infants
The impact of breastfeeding on the preterm infant’s microbiome and metabolome: a pilot study
Duration of skin-to-skin care and rectal temperatures in late preterm and term infants
Delicate attention
Delicate consideration
Vitamin D and gut microbiome in preterm infants
Meconium microbiome of very preterm infants across Germany
Dichotomous development of the gut microbiome in preterm infants
Prognosis of Full Thickness Skin Defects in Preterm Infants
Development of the preterm infant gut microbiome: a research priority
Intrauterine Inflammation, Epigenetics, and Microbiome Influences on Preterm Infant Health
Intravenous antibiotics in preterm infants have a negative effect upon microbiome development throughout preterm life
Early-life skin microbiota in hospitalized preterm and full-term infants
The impact of breastfeeding on the preterm infant’s microbiome and metabolome: a pilot study
Duration of skin-to-skin care and rectal temperatures in late preterm and term infants
Delicate attention