The Delicate Skin of Preterm Infants: Barrier Function, Immune-Microbiome Interaction, and Clinical Implications
The skin of preterm infants is a delicate organ with critical structural and functional differences as compared to term born infants. Unique features contribute to an increased susceptibility to injury, infection, thermal instability, and water loss. During rapid, often accelerated adaption of the physical barrier function of preterm skin, a parallel and mutual development of host skin immunity and skin microbiome seem to be crucial for skin homeostasis. Recent advances in molecular biology have enabled researchers to gain a deeper understanding of the microbial community composition of preterm skin and the important relationship with microbiome composition of other body sites. Nevertheless, several questions remain to be answered, including niche factors and environmental influences on skin maturation. In line with that, evidence-based guidelines on skin care practice in preterm infants are missing. This review articles aims to provide an overview of the current knowledge of preterm infant skin development including immune and barrier function, host-microbial interactions, and potential clinical implications.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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The Delicate Skin of Preterm Infants: Barrier Function, Immune-Microbiome Interaction, and Clinical Implications ; volume:120 ; number:3 ; year:2023 ; pages:295-307 ; extent:13
Neonatology ; 120, Heft 3 (2023), 295-307 (gesamt 13)
- Urheber
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Marissen, Janina
Gomez de Agüero, Mercedes
Chandorkar, Parul
Reichert, Lilith
Glaser, Kirsten
Speer, Christian P.
Härtel, Christoph
- DOI
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10.1159/000529026
- URN
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urn:nbn:de:101:1-2023072000185728523717
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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14.08.2025, 10:57 MESZ
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Marissen, Janina
- Gomez de Agüero, Mercedes
- Chandorkar, Parul
- Reichert, Lilith
- Glaser, Kirsten
- Speer, Christian P.
- Härtel, Christoph
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