DOT1L deletion impairs the development of cortical parvalbumin-expressing interneurons
Abstract: The cortical plate (CP) is composed of excitatory and inhibitory neurons, the latter of which originate in the ganglionic eminences. From their origin in the ventral telencephalon, maturing postmitotic interneurons migrate during embryonic development over some distance to reach their final destination in the CP. The histone methyltransferase Disruptor of Telomeric Silencing 1-like (DOT1L) is necessary for proper CP development and layer distribution of glutamatergic neurons. However, its specific role on cortical interneuron development has not yet been explored. Here, we demonstrate that DOT1L affects interneuron development in a cell autonomous manner. Deletion of Dot1l in Nkx2.1-expressing interneuron precursor cells results in an overall reduction and altered distribution of GABAergic interneurons in the CP from postnatal day 0 onwards. We observed an altered proportion of GABAergic interneurons in the cortex, with a significant decrease in parvalbumin-expressing interneurons. Moreover, a decreased number of mitotic cells at the embryonic day E14.5 was observed upon Dot1l deletion. Altogether, our results indicate that reduced numbers of cortical interneurons upon DOT1L deletion result from premature cell cycle exit, but effects on postmitotic differentiation, maturation, and migration are likely at play as well
- Location
-
Deutsche Nationalbibliothek Frankfurt am Main
- Extent
-
Online-Ressource
- Language
-
Englisch
- Notes
-
Cerebral cortex. - 33, 19 (2023) , 10272-10285, ISSN: 1460-2199
- Event
-
Veröffentlichung
- (where)
-
Freiburg
- (who)
-
Universität
- (when)
-
2023
- Creator
-
Cheffer, Arquimedes
Garcia Miralles, Marta
Maier, Esther M.
Akol, Ipek
Franz, Henriette
Srinivasan, Vandana Shree Vedartham
Vogel, Tanja
- DOI
-
10.1093/cercor/bhad281
- URN
-
urn:nbn:de:bsz:25-freidok-2386008
- Rights
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
-
14.08.2025, 10:58 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Cheffer, Arquimedes
- Garcia Miralles, Marta
- Maier, Esther M.
- Akol, Ipek
- Franz, Henriette
- Srinivasan, Vandana Shree Vedartham
- Vogel, Tanja
- Universität
Time of origin
- 2023
Other Objects (12)
Optogenetic silencing of Parvalbumin-expressing hippocampal interneurons
Parvalbumin-expressing interneurons in the medial entorhinal cortex
Intersectional strategy to study cortical inhibitory parvalbumin-expressing interneurons
Synaptic plasticity in parvalbumin expressing, perisomatic inhibitory interneurons of the dentate gyrus
Parvalbumin expressing interneurons control spike-phase coupling of hippocampal cells to theta oscillations
An efficient rAAV vector for protein expression in cortical parvalbumin expressing interneurons
Reduced Firing of Nucleus Accumbens Parvalbumin Interneurons Impairs Risk Avoidance in DISC1 Transgenic Mice
Dendritic inhibition differentially regulates excitability of dentate gyrus parvalbumin-expressing interneurons and granule cells
Anatomical and molecular characterization of parvalbumin-cholecystokinin co-expressing inhibitory interneurons: implications for neuropsychiatric conditions
NMDARs hypofunction in parvalbumin-expressing interneurons alters oscillations and sensory tuning in mouse primary visual cortex
Brain volumetric alterations accompanied with loss of striatal medium-sized spiny neurons and cortical parvalbumin expressing interneurons in Brd1 +/− mice
Experimentally constrained network model of hippocampal fast-firing parvalbumin-positive interneurons
Optogenetic silencing of Parvalbumin-expressing hippocampal interneurons
Parvalbumin-expressing interneurons in the medial entorhinal cortex
Intersectional strategy to study cortical inhibitory parvalbumin-expressing interneurons
Synaptic plasticity in parvalbumin expressing, perisomatic inhibitory interneurons of the dentate gyrus
Parvalbumin expressing interneurons control spike-phase coupling of hippocampal cells to theta oscillations
An efficient rAAV vector for protein expression in cortical parvalbumin expressing interneurons
Reduced Firing of Nucleus Accumbens Parvalbumin Interneurons Impairs Risk Avoidance in DISC1 Transgenic Mice
Dendritic inhibition differentially regulates excitability of dentate gyrus parvalbumin-expressing interneurons and granule cells
Anatomical and molecular characterization of parvalbumin-cholecystokinin co-expressing inhibitory interneurons: implications for neuropsychiatric conditions
NMDARs hypofunction in parvalbumin-expressing interneurons alters oscillations and sensory tuning in mouse primary visual cortex
Brain volumetric alterations accompanied with loss of striatal medium-sized spiny neurons and cortical parvalbumin expressing interneurons in Brd1 +/− mice
Experimentally constrained network model of hippocampal fast-firing parvalbumin-positive interneurons
Optogenetic silencing of Parvalbumin-expressing hippocampal interneurons
Parvalbumin-expressing interneurons in the medial entorhinal cortex
Intersectional strategy to study cortical inhibitory parvalbumin-expressing interneurons
Synaptic plasticity in parvalbumin expressing, perisomatic inhibitory interneurons of the dentate gyrus
Parvalbumin expressing interneurons control spike-phase coupling of hippocampal cells to theta oscillations
An efficient rAAV vector for protein expression in cortical parvalbumin expressing interneurons
Reduced Firing of Nucleus Accumbens Parvalbumin Interneurons Impairs Risk Avoidance in DISC1 Transgenic Mice
Dendritic inhibition differentially regulates excitability of dentate gyrus parvalbumin-expressing interneurons and granule cells
Anatomical and molecular characterization of parvalbumin-cholecystokinin co-expressing inhibitory interneurons: implications for neuropsychiatric conditions
NMDARs hypofunction in parvalbumin-expressing interneurons alters oscillations and sensory tuning in mouse primary visual cortex
Brain volumetric alterations accompanied with loss of striatal medium-sized spiny neurons and cortical parvalbumin expressing interneurons in Brd1 +/− mice