Impaired vascular relaxation in type 2 diabetes : A systematic review and meta-analysis
Abstract: Type 2 diabetes (T2D) significantly increases the risk of vascular complications (12-32 %), which are a major cause of death (over 50 %) in T2D patients. In T2D, both endothelial (ET) and vascular smooth muscle (VSM) cells are impaired, which act as independent risk factors for cardiovascular disease. Thus, the question of this systematic review and meta-analysis is: Do ET-dependent and -independent VSM relaxation impair in T2D? We systematically searched PubMed and Scopus databases until March 2024; 44 eligible clinical trial studies (68, 16, 30, and 50 study arms for acetylcholine (ACh), methacholine (MTH), sodium nitroprusside (SNP), and glyceryl trinitrate (GTN)) published were included. ET-dependent VSM relaxation in response to ACh (overall ES = -28.9 %, 95 % CI: -35.2, -22.7; p<0.001) and MTH (overall ES = -55.3 %, 95 % CI: -63.6, -47.1; p<0.001) decreased in T2D patients compared to controls. ET-independent VSM relaxation in response to SNP (overall ES = -17.2 %, 95 % CI: -.... https://www.excli.de/excli/article/view/7330
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Impaired vascular relaxation in type 2 diabetes ; volume:23 ; year:2024
EXCLI journal ; 23 (2024)
- Urheber
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Jeddi, Sajad
Bahadoran, Zahra
Mirmiran, Parvin
Kashfi, Khosrow
Ghasemi, Asghar
- DOI
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10.17179/excli2024-7330
- URN
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urn:nbn:de:101:1-2411080214096.702907303989
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
- 15.08.2025, 07:26 MESZ
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Beteiligte
- Jeddi, Sajad
- Bahadoran, Zahra
- Mirmiran, Parvin
- Kashfi, Khosrow
- Ghasemi, Asghar
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