Improving Cancer Detection and Treatment by pH‐Sensitive Peptide Nanoparticle Drug Delivery Platform: Pharmacokinetics, Toxicity, and Immunogenicity Profile

It was previously reported that a nanoparticle made of ultra pH‐sensitive peptides (pH‐NP) undergoes self‐dissolution in moderately acidic (pH ≤ 6.9) condition that mimics the pH in extracellular tumor environment, leading to release of drug cargo molecules. Herein, it is demonstrated that this peptide‐based nanodelivery platform can be used to formulate poorly water‐soluble small molecules to improve cancer diagnosis and treatment. Indocyanine green (ICG) encapsulated in pH‐NP (ICG‐pH‐NP) significantly increases tumor‐specific accumulation compared with “free” ICG, leading to excellent in vivo optical imaging contrast. An investigational cancer drug, OTS964, formulated in pH‐NP (OTS‐pH‐NP), sensitizes the drug‐resistant triple‐negative breast cancer to chemotherapy (paclitaxel), resulting in a remarkable tumor regression, whereas OTS964 in standard formulation does not (P = 0.0004). The potential immunogenicity and bone marrow toxicity of this nanoparticle are further investigated by administering drug‐free pH‐NP at nanoparticle dose regimens, representing 1.5× and 4.5×, respectively, of which are used in the treatment (OTS‐pH‐NP) study. The data show that the pH‐NP is not immunogenic and is well‐tolerated. Taken together, self‐dissolution and the release of drug cargo in response to the tumor's acidic extracellular pH faciliates drug delivery when mediated by the pH‐NP nano platform, making it a promising, clinical translational delivery platform for enhancing cancer detection and treatment.

Angaben zum Objekt

• Standort: Deutsche Nationalbibliothek Frankfurt am Main
• Umfang: Online-Ressource
• Sprache: Englisch

Verweise und Beziehungen

• Erschienen in: Improving Cancer Detection and Treatment by pH‐Sensitive Peptide Nanoparticle Drug Delivery Platform: Pharmacokinetics, Toxicity, and Immunogenicity Profile ; day:30 ; month:12 ; year:2021 ; extent:12 ; Advanced nanoBiomed research ; (30.12.2021) (gesamt 12)

Beteiligte, Orts- und Zeitangaben

• Urheber: Choi, Hoon ; Cao, Jianbo ; Qiao, Hui ; Chen, I-Wei ; Zhou, Rong

Weitere Informationen

• DOI: 10.1002/anbr.202100081
• URN: urn:nbn:de:101:1-2021123114143787076006
• Rechteinformation: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Letzte Aktualisierung: 15.08.2025, 07:39 MESZ