Organelle‐Targeting Nanoparticles
Abstract: Organelles are specialized subunits within cells which carry out vital functions crucial to cellular survival and form a tightly regulated network. Dysfunctions in any of these organelles are linked to numerous diseases impacting virtually every organ system in the human body. Targeted delivery of therapeutics to specific organelles within the cell holds great promise for overcoming challenging diseases and improving treatment outcomes through the minimization of therapeutic dosage and off‐target effects. Nanoparticles are versatile and effective tools for therapeutic delivery to specific organelles. Nanoparticles offer several advantageous characteristics, including a high surface area‐to‐volume ratio for efficient therapeutic loading and the ability to attach targeting moieties (tethers) that enhance delivery. The choice of nanoparticle shape, size, composition, surface properties, and targeting ligands depends on the desired target organelle and therapeutic effect. Various nanoparticle platforms have been explored for organelle targeting, such as liposomes, polymeric nanoparticles, dendrimers, and inorganic nanoparticles. In this review, current and emerging approaches to nanoparticle design are examined in the context of various diseases linked to organelle dysfunction. Specifically, advances in nanoparticle therapies targeting organelles such as the nucleus, mitochondria, lysosomes/endosomes, Golgi apparatus, and endoplasmic reticulum are comprehensively and critically discussed.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Organelle‐Targeting Nanoparticles ; day:13 ; month:01 ; year:2025 ; extent:17
Advanced science ; (13.01.2025) (gesamt 17)
- Creator
- DOI
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10.1002/advs.202411720
- URN
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urn:nbn:de:101:1-2501141321071.165533389690
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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18.04.2032, 1:37 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Soukar, John
- Peppas, Nicholas A.
- Gaharwar, A. K.
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Die Organelle der lebenden Pflanzenzelle (Allium cepa)
Determining targeting specificity of nuclearly encoded organelle proteins
Drug delivery systems for macrophage- and organelle-specific targeting
Organelle genetics : evolution of organelle genomes and gene expression
Cell-imaging studies of highly substituted oxazole derivatives as organelle targeting fluorophores (OTFPs)
Evolving a photosynthetic organelle
Cilia - the prodigal organelle
N-alkylaminoferrocenes for cancer-specific activation and/or organelle-targeting of known anticancer moieties
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The peroxisome: still a mysterious organelle
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Die Organelle der lebenden Pflanzenzelle (Allium cepa)
Determining targeting specificity of nuclearly encoded organelle proteins
Drug delivery systems for macrophage- and organelle-specific targeting
Organelle genetics : evolution of organelle genomes and gene expression
Cell-imaging studies of highly substituted oxazole derivatives as organelle targeting fluorophores (OTFPs)
Evolving a photosynthetic organelle
Cilia - the prodigal organelle
N-alkylaminoferrocenes for cancer-specific activation and/or organelle-targeting of known anticancer moieties
GetOrganelle: a fast and versatile toolkit for accurate de novo assembly of organelle genomes
Organelle dysfunction modulates cholesterol biosynthesis pathway
The peroxisome: still a mysterious organelle
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