One‐Pot Synthesis of Fluorinated Pyrimidine Derivatives from Aldehydes by Photocatalytic α‐Perfluoroalkenylation
Abstract: A straightforward, operationally simple and inexpensive one‐pot synthesis of substituted 4‐perfluoroalkyl‐pyrimidine derivatives is reported. Employing triphenylphosphine as a photocatalyst and an additional imidazolidinone organocatalyst, aldehydes undergo α‐perfluoroalkenylation giving highly electron‐deficient enals, which form the heterocycle upon condensation with a guanidinium salt. The method tolerates many functional groups and gives the corresponding products in up to 84 % yield over both steps.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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One‐Pot Synthesis of Fluorinated Pyrimidine Derivatives from Aldehydes by Photocatalytic α‐Perfluoroalkenylation ; day:09 ; month:02 ; year:2025 ; extent:6
European journal of organic chemistry ; (09.02.2025) (gesamt 6)
- Urheber
- DOI
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10.1002/ejoc.202500047
- URN
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urn:nbn:de:101:1-2502101307124.977489764135
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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15.08.2025, 07:23 MESZ
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Beteiligte
- Zhu, Yu‐Jun
- Czekelius, Constantin
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