Extracellular Vesicles in Cancer Immune Microenvironment and Cancer Immunotherapy
Abstract: Extracellular vesicles (EVs) are secreted by almost all cells. They contain proteins, lipids, and nucleic acids which are delivered from the parent cells to the recipient cells. Thereby, they function as mediators of intercellular communication and molecular transfer. Recent evidences suggest that exosomes, a small subset of EVs, are involved in numerous physiological and pathological processes and play essential roles in remodeling the tumor immune microenvironment even before the occurrence and metastasis of cancer. Exosomes derived from tumor cells and host cells mediate their mutual regulation locally or remotely, thereby determining the responsiveness of cancer therapies. As such, tumor‐derived circulating exosomes are considered as noninvasive biomarkers for early detection and diagnosis of tumor. Exosome‐based therapies are also emerging as cutting‐edge and promising strategies that could be applied to suppress tumor progression or enhance anti‐tumor immunity. Herein, the current understanding of exosomes and their key roles in modulating immune responses, as well as their potential therapeutic applications are outlined. The limitations of current studies are also presented and directions for future research are described.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Extracellular Vesicles in Cancer Immune Microenvironment and Cancer Immunotherapy ; volume:6 ; number:24 ; year:2019 ; extent:18
Advanced science ; 6, Heft 24 (2019) (gesamt 18)
- Creator
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Xie, Feng
Zhou, Xiaoxue
Fang, Meiyu
Li, Heyu
Su, Peng
Tu, Yifei
Zhang, Long
Zhou, Fangfang
- DOI
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10.1002/advs.201901779
- URN
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urn:nbn:de:101:1-2022071713104427896896
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:26 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Xie, Feng
- Zhou, Xiaoxue
- Fang, Meiyu
- Li, Heyu
- Su, Peng
- Tu, Yifei
- Zhang, Long
- Zhou, Fangfang
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