Bioinspired DNA Nanointerface with Anisotropic Aptamers for Accurate Capture of Circulating Tumor Cells
Abstract: The capture and analysis of circulating tumor cells (CTCs) have provided a non‐invasive entry for cancer diagnosis and disease monitoring. Despite recent development in affinity‐based CTCs isolation, it remains challenging to achieve efficient capture toward CTCs with dynamic surface expression. Enlightened by the synergistic effect insideimmune synapses, the development of a nanointerface engineered with topology‐defined anisotropic aptamers programmed by DNA scaffold (DNA nanosynapse), for accurate CTCs isolation, is herein reported. As compared to isotropic aptamers, the DNA nanosynapse exhibits enhanced anchoring on the cell membrane with both high and low epithelial cell adhesion molecule (EpCAM) expression. This nanointerface enables accurate capture toward CTCs of heterogeneous EpCAM, without dramatically proportional change inside the mixture of diverse phenotypes. By applying this nanoplatform, CTCs detection as well as downstream analysis for measuring disease status can be achieved in clinical samples from breast cancer patients.
- Standort
-
Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
-
Online-Ressource
- Sprache
-
Englisch
- Erschienen in
-
Bioinspired DNA Nanointerface with Anisotropic Aptamers for Accurate Capture of Circulating Tumor Cells ; volume:7 ; number:19 ; year:2020 ; extent:8
Advanced science ; 7, Heft 19 (2020) (gesamt 8)
- Urheber
- DOI
-
10.1002/advs.202000647
- URN
-
urn:nbn:de:101:1-2022062310074036796749
- Rechteinformation
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
-
15.08.2025, 07:26 MESZ
Datenpartner
Dieses Objekt wird bereitgestellt von:
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Qin, Weiwei
- Chen, Liang
- Wang, Zhiru
- Li, Qian
- Fan, Chunhai
- Wu, Minhao
- Zhang, Yuanqing
Ähnliche Objekte (12)
DKK1 promotes hepatocellular carcinoma cell migration and invasion through β-catenin/MMP7 signaling pathway
Comprehensive analyses of a CD8+ T cell infiltration related gene signature with regard to the prediction of prognosis and immunotherapy response in lung squamous cell carcinoma
scTour: a deep learning architecture for robust inference and accurate prediction of cellular dynamics
Adhesion studies of T-lymphocytes : insights into the adhesion dynamics of integrin-mediated inside-out signaling in response to TNF
Bioinformatics analysis to identify potential biomarkers for the pulmonary artery hypertension associated with the basement membrane
A blow-up result for a system of coupled viscoelastic equations with arbitrary positive initial energy
Gu xi la yi shu : = Die griechische Kunst
The Significance of Epidemic Plasmids in the Success of Multidrug-Resistant Drug Pandemic Extraintestinal Pathogenic Escherichia coli
Joint-product representation learning for domain generalization in classification and regression
Inference of kinship using spatial distributions of SNPs for genome-wide association studies
Gene expression analysis reveals that histone deacetylation sites may serve as partitions of chromatin gene expression domains
Studying alternative splicing regulatory networks through partial correlation analysis
DKK1 promotes hepatocellular carcinoma cell migration and invasion through β-catenin/MMP7 signaling pathway
Comprehensive analyses of a CD8+ T cell infiltration related gene signature with regard to the prediction of prognosis and immunotherapy response in lung squamous cell carcinoma
scTour: a deep learning architecture for robust inference and accurate prediction of cellular dynamics
Adhesion studies of T-lymphocytes : insights into the adhesion dynamics of integrin-mediated inside-out signaling in response to TNF
Bioinformatics analysis to identify potential biomarkers for the pulmonary artery hypertension associated with the basement membrane
A blow-up result for a system of coupled viscoelastic equations with arbitrary positive initial energy
Gu xi la yi shu : = Die griechische Kunst
The Significance of Epidemic Plasmids in the Success of Multidrug-Resistant Drug Pandemic Extraintestinal Pathogenic Escherichia coli
Joint-product representation learning for domain generalization in classification and regression
Inference of kinship using spatial distributions of SNPs for genome-wide association studies
Gene expression analysis reveals that histone deacetylation sites may serve as partitions of chromatin gene expression domains
Studying alternative splicing regulatory networks through partial correlation analysis
DKK1 promotes hepatocellular carcinoma cell migration and invasion through β-catenin/MMP7 signaling pathway
Comprehensive analyses of a CD8+ T cell infiltration related gene signature with regard to the prediction of prognosis and immunotherapy response in lung squamous cell carcinoma
scTour: a deep learning architecture for robust inference and accurate prediction of cellular dynamics
Adhesion studies of T-lymphocytes : insights into the adhesion dynamics of integrin-mediated inside-out signaling in response to TNF
Bioinformatics analysis to identify potential biomarkers for the pulmonary artery hypertension associated with the basement membrane
A blow-up result for a system of coupled viscoelastic equations with arbitrary positive initial energy
Gu xi la yi shu : = Die griechische Kunst
The Significance of Epidemic Plasmids in the Success of Multidrug-Resistant Drug Pandemic Extraintestinal Pathogenic Escherichia coli
Joint-product representation learning for domain generalization in classification and regression
Inference of kinship using spatial distributions of SNPs for genome-wide association studies
Gene expression analysis reveals that histone deacetylation sites may serve as partitions of chromatin gene expression domains