Self‐Adaptive Synthesis of Non‐Covalent Crosslinkers while Folding Single‐Chain Polymers
Abstract: Peptide folding is a dynamic process driven by non‐covalent cross‐linking leading to functional nanostructures for essential biochemical activities. However, replicating this process in synthetic systems is challenging due to the difficulty in mimicking nature‘s real‐time regulation of non‐covalent crosslinking for single‐chain polymer folding. Here, we address this by employing anionic dithiol building blocks to create macrocyclic disulfides as non‐covalent crosslinkers that adapted to the folding process. Initially, small macrocycles facilitated a low degree folding of a polycation. Then, this preorganized structure catalysed the production of larger macrocycles that enhanced the folding conversely. The self‐adaptive synthesis was verified through the encapsulation of an anticancer drug, showing an updated production distribution of non‐covalent crosslinkers and maximizing drug‐loading efficiency against drug‐resistant cancer in vitro. Our research advances the understanding of molecular systems by exploring species evolution via the structural dynamics of polymer folding. Additionally, adaptive synthesis enables controlled, sequential folding of synthetic polymers, with the potential to mimic protein functions.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Self‐Adaptive Synthesis of Non‐Covalent Crosslinkers while Folding Single‐Chain Polymers ; day:14 ; month:08 ; year:2024 ; extent:10
Angewandte Chemie / International edition. International edition ; (14.08.2024) (gesamt 10)
- Urheber
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Qi, Dawei
Shi, Xuncheng
Lin, Caihong
Holzhausen, Ferdinand
Ville, Liljeström
Sun, Xun
Luo, Jinghui
Pitkänen, Leena
Zhu, Ya
Rosenholm, Jessica
Jalkanen, Sirpa
Li, Jianwei
- DOI
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10.1002/anie.202408670
- URN
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urn:nbn:de:101:1-2408151405170.636766651012
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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14.08.2025, 10:49 MESZ
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Qi, Dawei
- Shi, Xuncheng
- Lin, Caihong
- Holzhausen, Ferdinand
- Ville, Liljeström
- Sun, Xun
- Luo, Jinghui
- Pitkänen, Leena
- Zhu, Ya
- Rosenholm, Jessica
- Jalkanen, Sirpa
- Li, Jianwei
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