Qualification of a Single‐Use Disk Stack Separator for Cell Separation in Mammalian Cell‐Based Antibody Production
Abstract: Single‐use technology is now an indispensable part of biopharmaceutical production processes. This not only applies to research and development, but also to commercial processes. The manufacturers of single‐use systems are working on improving them for use in intensified processes as well as on new developments. One of the bottlenecks was the availability of single‐use disk stack separators whose stainless steel variants are widely used in industry. In this study, the suitability of the new single‐use disk stack separator kytero 500 was investigated for the first time for cell separation in pilot‐scale Chinese hamster ovary cell‐based antibody production. The cells were completely separated over a wide range of separator settings with nearly no release of intracellular substances and no loss of the antibody.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Qualification of a Single‐Use Disk Stack Separator for Cell Separation in Mammalian Cell‐Based Antibody Production ; day:08 ; month:11 ; year:2022 ; extent:9
Chemie - Ingenieur - Technik ; (08.11.2022) (gesamt 9)
- Creator
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Ott, Vivian
Müller, Jan
Schirmer, Cedric
Weiss, Noémi
Göhmann, Rüdiger
Biewald, Andreas
Michel, Andrej
Eibl, Dieter
Eibl, Regine
- DOI
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10.1002/cite.202200096
- URN
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urn:nbn:de:101:1-2022110914053968586584
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:21 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Ott, Vivian
- Müller, Jan
- Schirmer, Cedric
- Weiss, Noémi
- Göhmann, Rüdiger
- Biewald, Andreas
- Michel, Andrej
- Eibl, Dieter
- Eibl, Regine
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