Filamentous‐Actin‐Mimicking Nanoplatform for Enhanced Cytosolic Protein Delivery
Abstract: Despite the potential of protein therapeutics, the cytosolic delivery of proteins with high efficiency and bioactivity remains a significant challenge owing to exocytosis and lysosomal degradation after endocytosis. Therefore, it is important to develop a safe and efficient strategy to bypass endocytosis. Inspired by the extraordinary capability of filamentous‐actin (F‐actin) to promote cell membrane fusion, a cyanine dye assembly‐containing nanoplatform mimicking the structure of natural F‐actin is developed. The nanoplatform exhibits fast membrane fusion to cell membrane mimics and thus enters live cells through membrane fusion and bypasses endocytosis. Moreover, it is found to efficiently deliver protein cargos into live cells and quickly release them into the cytosol, leading to high protein cargo transfection efficiency and bioactivity. The nanoplatform also results in the superior inhibition of tumor cells when loaded with anti‐tumor proteins. These results demonstrate that this fusogenic nanoplatform can be valuable for cytosolic protein delivery and tumor treatment.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Filamentous‐Actin‐Mimicking Nanoplatform for Enhanced Cytosolic Protein Delivery ; day:28 ; month:12 ; year:2023 ; extent:13
Advanced science ; (28.12.2023) (gesamt 13)
- Creator
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Xia, Yuqiong
Wu, Keyun
Liu, Chang
Zhao, Xuejuan
Wang, Jun
Cao, Jianxia
Chen, Zhaoxu
Fang, Minchao
Yu, Jie
Zhu, Cheng
Zhang, Xianghan
Wang, Zhongliang
- DOI
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10.1002/advs.202305600
- URN
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urn:nbn:de:101:1-2023122814280736283680
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:39 AM CEST
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Associated
- Xia, Yuqiong
- Wu, Keyun
- Liu, Chang
- Zhao, Xuejuan
- Wang, Jun
- Cao, Jianxia
- Chen, Zhaoxu
- Fang, Minchao
- Yu, Jie
- Zhu, Cheng
- Zhang, Xianghan
- Wang, Zhongliang
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