Thoroughly Hydrophilized Electrospun Poly (L ‐Lactide)/Poly (ε ‐Caprolactone) Sponges for Tissue Engineering Application

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Abstract: Biodegradable electrospun sponges are of interest for various applications including tissue engineering, drug release, dental therapy, plant protection, and plant fertilization. Biodegradable electrospun poly (l ‐lactide)/poly (ε‐caprolactone) (PLLA/PCL) blend fiber‐based sponge with hierarchical pore structure is inherently hydrophobic, which is disadvantageous for application in tissue engineering, fertilization, and drug delivery. Contact angles and model studies for staining with a hydrophilic dye for untreated, plasma‐treated, and surfactant‐treated PLLA/PCL sponges are reported. Thorough hydrophilization of PLLA/PCL sponges is found only with surfactant‐treated sponges. The MTT assay on the leachates from the sponges does not indicate any cell incompatibility. Furthermore, the cell proliferation and penetration of the hydrophilized sponges are verified by in vitro cell culture studies using MG63 and human fibroblast cells.

Standort
Deutsche Nationalbibliothek Frankfurt am Main
Umfang
Online-Ressource
Sprache
Englisch

Erschienen in
Thoroughly Hydrophilized Electrospun Poly (L ‐Lactide)/Poly (ε ‐Caprolactone) Sponges for Tissue Engineering Application ; day:06 ; month:07 ; year:2023 ; extent:11
Macromolecular bioscience ; (06.07.2023) (gesamt 11)

Urheber
Xu, Chengzhang
Cheong, Jun Young
Mo, Xiumei
Jérôme, Valérie
Freitag, Ruth
Agarwal, Seema
Gharibi, Reza
Greiner, Andreas

DOI
10.1002/mabi.202300143
URN
urn:nbn:de:101:1-2023070615202786953767
Rechteinformation
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
Letzte Aktualisierung
14.08.2025, 10:56 MESZ

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