Stereoselective Transaminase‐Mediated Synthesis of Serotonin and Melatonin Receptor Agonists
Abstract: Transaminase enzymes have significant potential for the stereoselective synthesis of drugs or drug precursors. Here, starting from one prochiral β‐tetralone, a short and efficient chemoenzymatic synthesis of four agonists of the serotonin/melatonin receptors have been developed. The key step is the stereoselective transamination of the prochiral ketone to produce both enantiomers of 8‐methoxy‐2‐aminotetraline in high yields and enantiomeric excesses. This was followed by either amidation to give the 8‐methoxy‐2‐acetimidotetralines or several facile chemical steps to the 8‐hydroxy‐2‐aminodipropyltetralines.
- Standort
-
Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
-
Online-Ressource
- Sprache
-
Englisch
- Erschienen in
-
Stereoselective Transaminase‐Mediated Synthesis of Serotonin and Melatonin Receptor Agonists ; day:08 ; month:04 ; year:2022 ; extent:1
Advanced synthesis & catalysis ; (08.04.2022) (gesamt 1)
- Urheber
-
Baud, Damien
Tappertzhofen, Nadine
Moody, Thomas S.
Ward, John M.
Hailes, Helen C.
- DOI
-
10.1002/adsc.202200146
- URN
-
urn:nbn:de:101:1-2022041215121778900991
- Rechteinformation
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
-
15.08.2025, 07:35 MESZ
Datenpartner
Dieses Objekt wird bereitgestellt von:
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Baud, Damien
- Tappertzhofen, Nadine
- Moody, Thomas S.
- Ward, John M.
- Hailes, Helen C.
Ähnliche Objekte (12)
Pharmakotherapie der Depression : Bedeutung von Serotonin u. Melatonin
Melatonin and melatonin agonists to prevent and treat delirium in critical illness: a systematic review protocol
Stereoselective cell uptake of adrenergic agonists and antagonists by organic cation transporters
Melatonin, but not melatonin receptor agonists Neu-P11 and Neu-P67, attenuates TNBS-induced colitis in mice
The genomic response of human granulosa cells (KGN) to melatonin and specific agonists/antagonists to the melatonin receptors
Chirality of β 2 -agonists. An overview of pharmacological activity, stereoselective analysis, and synthesis
Impact of UVA exposure on psychological parameters and circulating serotonin and melatonin
Monitoring Gut Epithelium Serotonin and Melatonin Overflow Provides Spatial Mapping of Inflammation
Location and orientation of serotonin receptor 1a agonists in model and complex lipid membranes
Untersuchung zum Melatonin-, Serotonin- und N-Azetyl-Serotoningehalt in Pinealorganen von Suizid und Nichtsuizidopfern
Stereoselective synthesis
Stereoselective Synthesis
Pharmakotherapie der Depression : Bedeutung von Serotonin u. Melatonin
Melatonin and melatonin agonists to prevent and treat delirium in critical illness: a systematic review protocol
Stereoselective cell uptake of adrenergic agonists and antagonists by organic cation transporters
Melatonin, but not melatonin receptor agonists Neu-P11 and Neu-P67, attenuates TNBS-induced colitis in mice
The genomic response of human granulosa cells (KGN) to melatonin and specific agonists/antagonists to the melatonin receptors
Chirality of β 2 -agonists. An overview of pharmacological activity, stereoselective analysis, and synthesis
Impact of UVA exposure on psychological parameters and circulating serotonin and melatonin
Monitoring Gut Epithelium Serotonin and Melatonin Overflow Provides Spatial Mapping of Inflammation
Location and orientation of serotonin receptor 1a agonists in model and complex lipid membranes
Untersuchung zum Melatonin-, Serotonin- und N-Azetyl-Serotoningehalt in Pinealorganen von Suizid und Nichtsuizidopfern
Stereoselective synthesis
Stereoselective Synthesis
Pharmakotherapie der Depression : Bedeutung von Serotonin u. Melatonin
Melatonin and melatonin agonists to prevent and treat delirium in critical illness: a systematic review protocol
Stereoselective cell uptake of adrenergic agonists and antagonists by organic cation transporters
Melatonin, but not melatonin receptor agonists Neu-P11 and Neu-P67, attenuates TNBS-induced colitis in mice
The genomic response of human granulosa cells (KGN) to melatonin and specific agonists/antagonists to the melatonin receptors
Chirality of β 2 -agonists. An overview of pharmacological activity, stereoselective analysis, and synthesis
Impact of UVA exposure on psychological parameters and circulating serotonin and melatonin
Monitoring Gut Epithelium Serotonin and Melatonin Overflow Provides Spatial Mapping of Inflammation
Location and orientation of serotonin receptor 1a agonists in model and complex lipid membranes
Untersuchung zum Melatonin-, Serotonin- und N-Azetyl-Serotoningehalt in Pinealorganen von Suizid und Nichtsuizidopfern
Stereoselective synthesis