Oral Carbon Monoxide Enhances Autophagy Modulation in Prostate, Pancreatic, and Lung Cancers
Abstract: Modulation of autophagy, specifically its inhibition, stands to transform the capacity to effectively treat a broad range of cancers. However, the clinical efficacy of autophagy inhibitors has been inconsistent. To delineate clinical and epidemiological features associated with autophagy inhibition and a positive oncological clinical response, a retrospective analysis of patients is conducted treated with hydroxychloroquine, a known autophagy inhibitor. A direct correlation between smoking status and inhibition of autophagy with hydroxychloroquine is identified. Recognizing that smoking is associated with elevated circulating levels of carbon monoxide (CO), it is hypothesized that supplemental CO can amplify autophagy inhibition. A novel, gas‐entrapping material containing CO in a pre‐clinical model is applied and demonstrated that CO can dramatically increase the cytotoxicity of autophagy inhibitors and significantly inhibit the growth of tumors when used in combination. These data support the notion that safe, therapeutic levels of CO can markedly enhance the efficacy of autophagy inhibitors, opening a promising new frontier in the quest to improve cancer therapies.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Oral Carbon Monoxide Enhances Autophagy Modulation in Prostate, Pancreatic, and Lung Cancers ; day:12 ; month:12 ; year:2023 ; extent:13
Advanced science ; (12.12.2023) (gesamt 13)
- Urheber
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Bi, Jianling
Witt, Emily
McGovern, Megan K.
Cafi, Arielle B.
Rosenstock, Lauren L.
Pearson, Anna B.
Brown, Timothy J.
Karasic, Thomas B.
Absler, Lucas C.
Machkanti, Srija
Boyce, Hannah
Gallo, David
Becker, Sarah L.
Ishida, Keiko
Jenkins, Joshua
Hayward, Alison
Scheiflinger, Alexandra
Bodeker, Kellie L.
Kumar, Ritesh
Shaw, Scott K.
Jabbour, Salma K.
Lira, Vitor A.
Henry, Michael D.
Tift, Michael S.
Otterbein, Leo E.
Traverso, Giovanni
Byrne, James D.
- DOI
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10.1002/advs.202308346
- URN
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urn:nbn:de:101:1-2023121214294235477619
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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15.08.2020, 07:22 MESZ
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Bi, Jianling
- Witt, Emily
- McGovern, Megan K.
- Cafi, Arielle B.
- Rosenstock, Lauren L.
- Pearson, Anna B.
- Brown, Timothy J.
- Karasic, Thomas B.
- Absler, Lucas C.
- Machkanti, Srija
- Boyce, Hannah
- Gallo, David
- Becker, Sarah L.
- Ishida, Keiko
- Jenkins, Joshua
- Hayward, Alison
- Scheiflinger, Alexandra
- Bodeker, Kellie L.
- Kumar, Ritesh
- Shaw, Scott K.
- Jabbour, Salma K.
- Lira, Vitor A.
- Henry, Michael D.
- Tift, Michael S.
- Otterbein, Leo E.
- Traverso, Giovanni
- Byrne, James D.
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