Bevacizumab cured age-related macular degeneration (AMD) via down-regulate TLR2 pathway
Abstract: AMD is the main cause of visual impairment in people over 50 years of age and the most common cause of blindness. In recent years, the use of bevacizumab to treat neovascular AMD has become a preferred treatment in the United States. However, whether bevacozumab is available for RPE or AMD patients is unknown. We firstly indicate that Pam3CSK4 (P3C) activates TLR2 pathway during ARPE-19 apoptosis as determined by western blotting. And then, the expression of MyD88, NF-κB, p-IKK in primary RPE cells from AMD patients is significantly down-regulated after treatment with 50 µg L−1 Bevacizumab. Therefore, our data shows that MyD88 is involved in the TLR2 pathway in ARPE-19 cell apoptosis resulting from Pam3CSK4 (P3C). And more importantly, our findings suggested that Bevacizumab cured age-related macular degeneration (AMD) via down-regulate Toll—like receptor 2 (TLR2) pathway in RPE from AMD patients.
- Location
-
Deutsche Nationalbibliothek Frankfurt am Main
- Extent
-
Online-Ressource
- Language
-
Englisch
- Bibliographic citation
-
Bevacizumab cured age-related macular degeneration (AMD) via down-regulate TLR2 pathway ; volume:9 ; number:5 ; year:2014 ; pages:469-475 ; extent:7
Open life sciences ; 9, Heft 5 (2014), 469-475 (gesamt 7)
- Creator
-
Wang, Zhi
Qiao, Bao
Li, Guo
Li, Shi
Wang, Li
Dong, Ying
- DOI
-
10.2478/s11535-014-0290-5
- URN
-
urn:nbn:de:101:1-2409211603270.352735391086
- Rights
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
-
15.08.2025, 7:39 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Wang, Zhi
- Qiao, Bao
- Li, Guo
- Li, Shi
- Wang, Li
- Dong, Ying
Other Objects (12)
Geschenkte Zeit, verschenkte Zeit : wie Jugendliche in Deutschland und China ihre Zeit nutzen
Hot tearing of Mg-Y and Mg-Y-Zn alloys
The Chinese Export Bundles: Patterns, Puzzles and Possible Explanations
Fractional Brownian sheet and martingale difference random fields
Nonlocal stochastic integro-differential equations driven by fractional Brownian motion
CO 2 Absorption of Powdered Ba 2 Fe 2 O 5 with Different Particle Size
Mechanical properties of epoxy resin toughened with cornstarch
The Domestic Segment of Global Supply Chains in China under State Capitalism
Extending the Input-Output Table Based on Firm-level Data
Does a Leapfrogging Growth Strategy Raise Growth Rate? Some International Evidence
Global value chains and effective exchange rates at the country-sector level
How vertically specialized is Chinese trade?
Geschenkte Zeit, verschenkte Zeit : wie Jugendliche in Deutschland und China ihre Zeit nutzen
Hot tearing of Mg-Y and Mg-Y-Zn alloys
The Chinese Export Bundles: Patterns, Puzzles and Possible Explanations
Fractional Brownian sheet and martingale difference random fields
Nonlocal stochastic integro-differential equations driven by fractional Brownian motion
CO 2 Absorption of Powdered Ba 2 Fe 2 O 5 with Different Particle Size
Mechanical properties of epoxy resin toughened with cornstarch
The Domestic Segment of Global Supply Chains in China under State Capitalism
Extending the Input-Output Table Based on Firm-level Data
Does a Leapfrogging Growth Strategy Raise Growth Rate? Some International Evidence
Global value chains and effective exchange rates at the country-sector level
How vertically specialized is Chinese trade?
Geschenkte Zeit, verschenkte Zeit : wie Jugendliche in Deutschland und China ihre Zeit nutzen
Hot tearing of Mg-Y and Mg-Y-Zn alloys
The Chinese Export Bundles: Patterns, Puzzles and Possible Explanations
Fractional Brownian sheet and martingale difference random fields
Nonlocal stochastic integro-differential equations driven by fractional Brownian motion
CO 2 Absorption of Powdered Ba 2 Fe 2 O 5 with Different Particle Size
Mechanical properties of epoxy resin toughened with cornstarch
The Domestic Segment of Global Supply Chains in China under State Capitalism
Extending the Input-Output Table Based on Firm-level Data
Does a Leapfrogging Growth Strategy Raise Growth Rate? Some International Evidence
Global value chains and effective exchange rates at the country-sector level