Microglia contribute to the propagation of A[beta] into unaffected brain tissue
Abstract: Microglia appear activated in the vicinity of amyloid beta (Aβ) plaques, but whether microglia contribute to Aβ propagation into unaffected brain regions remains unknown. Using transplantation of wild-type (WT) neurons, we show that Aβ enters WT grafts, and that this is accompanied by microglia infiltration. Manipulation of microglia function reduced Aβ deposition within grafts. Furthermore, in vivo imaging identified microglia as carriers of Aβ pathology in previously unaffected tissue. Our data thus argue for a hitherto unexplored mechanism of Aβ propagation
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Notes
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Nature neuroscience. - 25, 1 (2022) , 20-25, ISSN: 1546-1726
- Event
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Veröffentlichung
- (where)
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Freiburg
- (who)
-
Universität
- (when)
-
2021
- Creator
-
Errico, Paolo d'
Ziegler-Waldkirch, Stephanie
Aires, Vanessa
Hoffmann, Philippe
Mezö, Charlotte
Erny, Daniel
Monasor, Laura Sebastian
Liebscher, Sabine
Ravi, Vidhya M.
Joseph, Kevin
Schnell, Oliver
Kierdorf, Katrin
Staszewski, Ori
Tahirovic, Sabina
Prinz, Marco
Meyer-Lühmann, Melanie
- DOI
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10.1038/s41593-021-00951-0
- URN
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urn:nbn:de:bsz:25-freidok-2228301
- Rights
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
-
15.08.2025, 7:22 AM CEST
Data provider
This object is provided by:
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Errico, Paolo d'
- Ziegler-Waldkirch, Stephanie
- Aires, Vanessa
- Hoffmann, Philippe
- Mezö, Charlotte
- Erny, Daniel
- Monasor, Laura Sebastian
- Liebscher, Sabine
- Ravi, Vidhya M.
- Joseph, Kevin
- Schnell, Oliver
- Kierdorf, Katrin
- Staszewski, Ori
- Tahirovic, Sabina
- Prinz, Marco
- Meyer-Lühmann, Melanie
- Universität
Time of origin
- 2021
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