Identification of ß‐Glucocerebrosidase Activators for Glucosylceramide hydrolysis
Abstract: Several novel chemical series were identified that modulate glucocerebrosidase (GCase). Compounds from these series are active on glucosylceramide, unlike other known GCase modulators. We obtained GCase crystal structures with two compounds that have distinct chemotypes. Positive allosteric modulators bind to a site on GCase and induce conformational changes, but also induce an equilibrium state between monomer and dimer.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Identification of ß‐Glucocerebrosidase Activators for Glucosylceramide hydrolysis ; day:21 ; month:02 ; year:2024 ; extent:11
ChemMedChem ; (21.02.2024) (gesamt 11)
- Creator
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Schulze, Monika‐Sarah E. D.
Scholz, Diana
Jnoff, Eric
Hall, Adrian
Melin, Jonathan
Sands, Zara A.
Rodriguez, Elizabeth
Andre, Veronique M.
- DOI
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10.1002/cmdc.202300548
- URN
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urn:nbn:de:101:1-2024022214294115013985
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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14.08.2025, 10:58 AM CEST
Data provider
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Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Schulze, Monika‐Sarah E. D.
- Scholz, Diana
- Jnoff, Eric
- Hall, Adrian
- Melin, Jonathan
- Sands, Zara A.
- Rodriguez, Elizabeth
- Andre, Veronique M.
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