Promising Pharmacological Interventions for Posterior Capsule Opacification: A Review
Abstract: Phacoemulsification combined with intraocular lens implantation is the primary treatment for cataract. Although this treatment strategy benefits patients with cataracts, posterior capsule opacification (PCO) remains a common complication that impairs vision and affects treatment outcomes. The pathogenesis of PCO is associated with the proliferation, migration, and fibrogenesis activity of residual lens epithelial cells, with epithelial–mesenchymal transition (EMT) serving as a key mechanism underlying the condition. Transforming growth factor‐beta 2 (TGF‐β2) is a major promotor of EMT, thereby driving PCO development. Most studies have shown that drugs and miRNAs mitigate EMT by inhibiting, clearing, or eliminating LECs. In addition, targeting EMT–related signaling pathways in TGF‐β2–stimulated LECs has garnered attention as a research focus. This review highlights potential treatments for PCO and details the mechanisms by which drugs and miRNAs counter EMT.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Promising Pharmacological Interventions for Posterior Capsule Opacification: A Review ; day:12 ; month:11 ; year:2024 ; extent:10
Global challenges ; (12.11.2024) (gesamt 10)
- Creator
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Liu, Yuxuan
Dong, Xiaoming
Wu, Bin
Cheng, Zhigang
Zhang, Jinsong
Wang, Jing
- DOI
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10.1002/gch2.202400181
- URN
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urn:nbn:de:101:1-2411121347035.804869266924
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:24 AM CEST
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Associated
- Liu, Yuxuan
- Dong, Xiaoming
- Wu, Bin
- Cheng, Zhigang
- Zhang, Jinsong
- Wang, Jing
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