Titin: central player of hypertrophic signaling and sarcomeric protein quality control
Abstract: The giant sarcomeric protein titin has multiple important functions in striated muscle cells. Due to its gigantic size, its central position in the sarcomere and its elastic I-band domains, titin is a scaffold protein that is important for sarcomere assembly, and serves as a molecular spring that defines myofilament distensibility. This review focuses on the emerging role of titin in mechanosensing and hypertrophic signaling, and further highlights recent evidence that links titin to sarcomeric protein turnover.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Titin: central player of hypertrophic signaling and sarcomeric protein quality control ; volume:395 ; number:11 ; year:2014 ; pages:1341-1352 ; extent:12
Biological chemistry ; 395, Heft 11 (2014), 1341-1352 (gesamt 12)
- Creator
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Kötter, Sebastian
Andresen, Christian
Krüger, Martina
- DOI
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10.1515/hsz-2014-0178
- URN
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urn:nbn:de:101:1-2408051739548.829023616341
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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14.08.2025, 10:54 AM CEST
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Associated
- Kötter, Sebastian
- Andresen, Christian
- Krüger, Martina
Other Objects (12)
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Interaktion von Titin mit E3-Ubiquitin-Ligasen und Titin-Umbau in Langzeitkultivierung adulter Rattenkardiomyozyten
The titin N2B and N2A regions: biomechanical and metabolic signaling hubs in cross-striated muscles
The impact of the cGMP-PKG signaling pathway on titin modulation and cardiomyocyte stiffness
Alteration in mitochondrial Ca2+ uptake disrupts insulin signaling in hypertrophic cardiomyocytes
Molecular insights into titin’s A-band
Molecular insights into titin’s A-band
Titin-Degradationsprodukte als potentielle Biomarker für Herzerkrankungen
Elucidating the role of Titin mutations and the Titin-Nexilin interaction on the pathogenesis of dilated cardiomyopathy in zebrafish
Genetische Entschlüsselung der Struktur des Titin- und Nebulinfilamentsystems
Modulation of titin-based stiffness in hypertrophic cardiomyopathy via protein kinase D
Titin kinase signaling in cardiac hypertrophy and heart failure
Bioinspirierte Titin-analoge Polymere
Interaktion von Titin mit E3-Ubiquitin-Ligasen und Titin-Umbau in Langzeitkultivierung adulter Rattenkardiomyozyten
The titin N2B and N2A regions: biomechanical and metabolic signaling hubs in cross-striated muscles
The impact of the cGMP-PKG signaling pathway on titin modulation and cardiomyocyte stiffness
Alteration in mitochondrial Ca2+ uptake disrupts insulin signaling in hypertrophic cardiomyocytes
Molecular insights into titin’s A-band
Molecular insights into titin’s A-band
Titin-Degradationsprodukte als potentielle Biomarker für Herzerkrankungen
Elucidating the role of Titin mutations and the Titin-Nexilin interaction on the pathogenesis of dilated cardiomyopathy in zebrafish
Genetische Entschlüsselung der Struktur des Titin- und Nebulinfilamentsystems
Modulation of titin-based stiffness in hypertrophic cardiomyopathy via protein kinase D
Titin kinase signaling in cardiac hypertrophy and heart failure
Bioinspirierte Titin-analoge Polymere
Interaktion von Titin mit E3-Ubiquitin-Ligasen und Titin-Umbau in Langzeitkultivierung adulter Rattenkardiomyozyten
The titin N2B and N2A regions: biomechanical and metabolic signaling hubs in cross-striated muscles
The impact of the cGMP-PKG signaling pathway on titin modulation and cardiomyocyte stiffness
Alteration in mitochondrial Ca2+ uptake disrupts insulin signaling in hypertrophic cardiomyocytes
Molecular insights into titin’s A-band
Molecular insights into titin’s A-band
Titin-Degradationsprodukte als potentielle Biomarker für Herzerkrankungen
Elucidating the role of Titin mutations and the Titin-Nexilin interaction on the pathogenesis of dilated cardiomyopathy in zebrafish