Efficacy of automated fasteners versus hand-tied knots in cardiac surgery : a systematic review and meta-analysis

Abstract: Valve surgery is common in cardiac procedures, with fasteners like COR-KNOT® and hand-tied knots used for knot securing. This study compares their efficacy in valve surgery patients. We searched PubMed, SCOPUS, and Cochrane Central until August 2023. Outcomes assessed included aortic cross-clamp time (AXT), cardiopulmonary bypass (CPB) time, valvular regurgitation, mortality, prolonged ventilatory support, atrial fibrillation, postoperative left ventricular ejection fraction (LVEF), and renal failure. Subgroup analysis was performed for minimally invasive and open cardiac surgery. We used a random effects model for analysis. We included eight observational studies and two randomized controlled trials (RCTs) with a total of 1.411 participants. COR-KNOT significantly reduced AXT [MD -15.14, 95 % CI (-18.57, -11.70), P<0.00001] and CPB time [MD -12.38, 95 % CI (-14.99, -9.77), P<0.00001]. Valvular regurgitation [RR 0.40, 95 % CI (0.26, 0.61), P<0.0001] and need for prolonged ventilato.... https://www.excli.de/index.php/excli/article/view/6885

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Efficacy of automated fasteners versus hand-tied knots in cardiac surgery ; volume:23 ; year:2024 ; EXCLI journal ; 23 (2024)

Contributors, Places and Time

• Creator: Tharwani, Zoaib Habib ; Abdul Qadeer, Muhammad ; Abdullah, Ali ; Ali, Rubab ; Chaudhary, Muhammad Ahmed ; Qazi, Shurjeel Uddin ; Said, Sameh M.

Further information

• DOI: 10.17179/excli2023-6885
• URN: urn:nbn:de:101:1-2024030802152974635848
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 14.08.2025, 10:45 AM CEST