Lipidic Aminoglycoside Derivatives: A New Class of Immunomodulators Inducing a Potent Innate Immune Stimulation

to related objects

Abstract: Development of simple and fully characterized immunomodulatory molecules is an active area of research to enhance current immunotherapies. Monophosphoryl lipid A (MPL), a nontoxic lipidic derivative from bacteria, is the first and currently only adjuvant approved in humans. However, its capacity to induce a potent response against weak immunogenic tumoral‐associated antigens remains limited. Herein, a new generation of lipidic immunomodulators to conduct a structure–activity relationship study to determine the minimal structural elements conferring immunomodulatory properties is introduced. Two lead molecules characterized by a short succinyl linker between two oleyl chains and a polar headgroup consisting of either naturally occurring tobramycin (DOST) or kanamycin (DOSK) are identified. These two lipoaminoglycosides self‐assemble in very small vesicles. In a wide variety of cells including 3D human cell culture, DOST and DOSK induce the upregulation of proinflammatory cytokines and interferon‐inducible proteins in a dose and time‐dependent manner via a caveolae‐dependent proinflammatory mechanism and phosphatidylinositol phospholipase C activation. Furthermore, after intratumoral administration, these lipoaminoglycosides induce an efficient immune response leading to significant antitumor activity in a mouse breast cancer model. Altogether, these findings indicate that DOST and DOSK are two groundbreaking synthetic lipid immunostimulators that can be used as adjuvants to enhance current immunotherapeutic treatments.

Location: Deutsche Nationalbibliothek Frankfurt am Main

Extent: Online-Ressource

Language: Englisch

Bibliographic citation: Lipidic Aminoglycoside Derivatives: A New Class of Immunomodulators Inducing a Potent Innate Immune Stimulation ; volume:6 ; number:16 ; year:2019 ; extent:13
Advanced science ; 6, Heft 16 (2019) (gesamt 13)

Creator: Colombani, Thibault
Haudebourg, Thomas
Decossas, Marion
Lambert, Olivier
Ada Da Silva, Grace
Altare, Frederic
Pitard, Bruno

DOI: 10.1002/advs.201900288

URN: urn:nbn:de:101:1-2022080307281508724280

Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.

Last update: 15.08.2025, 7:25 AM CEST

Data provider

This object is provided by:
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.

Show original at data provider

Associated

Colombani, Thibault
Haudebourg, Thomas
Decossas, Marion
Lambert, Olivier
Ada Da Silva, Grace
Altare, Frederic
Pitard, Bruno

Other Objects (12)

Anticancer Aminoferrocene Derivatives Inducing Production of Mitochondrial Reactive Oxygen Species

Cigarette smoke aggravates asthma by inducing memory-like type 3 innate lymphoid cells

ERPs in an oddball task under vection-inducing visual stimulation

Coumarin linked to 2-phenylbenzimidazole derivatives as potent α-glucosidase inhibitors

Docking studies of flavonoid derivatives as potent HIV-1 integrase inhibitors

A new approach of inducing proprioceptive illusion by transcutaneous electrical stimulation

Discovery of Novel N-Acylhydrazone Derivatives as Potent Inhibitors of Sirtuin-1

Investigating the Effects of Chronic Stimulation of Innate Antiviral Immune Responses

Thioquinoline derivatives conjugated to thiosemicarbazide as potent tyrosinase inhibitors with anti-melanogenesis properties

SYNTHESIS OF SOME NEW UNSYMMETRICAL 1,4-DIHYDROPYRIDINE DERIVATIVES AS POTENT ANTITUBERCULAR AGENTS

Thioester derivatives of the natural product psammaplin A as potent histone deacetylase inhibitors

Theoretical investigation and design of some indole derivatives as potent β-glucuronidase inhibitors

Anticancer Aminoferrocene Derivatives Inducing Production of Mitochondrial Reactive Oxygen Species

Cigarette smoke aggravates asthma by inducing memory-like type 3 innate lymphoid cells

ERPs in an oddball task under vection-inducing visual stimulation

Coumarin linked to 2-phenylbenzimidazole derivatives as potent α-glucosidase inhibitors

Docking studies of flavonoid derivatives as potent HIV-1 integrase inhibitors

A new approach of inducing proprioceptive illusion by transcutaneous electrical stimulation

Discovery of Novel N-Acylhydrazone Derivatives as Potent Inhibitors of Sirtuin-1

Investigating the Effects of Chronic Stimulation of Innate Antiviral Immune Responses

Thioquinoline derivatives conjugated to thiosemicarbazide as potent tyrosinase inhibitors with anti-melanogenesis properties

SYNTHESIS OF SOME NEW UNSYMMETRICAL 1,4-DIHYDROPYRIDINE DERIVATIVES AS POTENT ANTITUBERCULAR AGENTS

Thioester derivatives of the natural product psammaplin A as potent histone deacetylase inhibitors

Theoretical investigation and design of some indole derivatives as potent β-glucuronidase inhibitors

Anticancer Aminoferrocene Derivatives Inducing Production of Mitochondrial Reactive Oxygen Species

Cigarette smoke aggravates asthma by inducing memory-like type 3 innate lymphoid cells

ERPs in an oddball task under vection-inducing visual stimulation

Coumarin linked to 2-phenylbenzimidazole derivatives as potent α-glucosidase inhibitors

Docking studies of flavonoid derivatives as potent HIV-1 integrase inhibitors

A new approach of inducing proprioceptive illusion by transcutaneous electrical stimulation

Discovery of Novel N-Acylhydrazone Derivatives as Potent Inhibitors of Sirtuin-1

Investigating the Effects of Chronic Stimulation of Innate Antiviral Immune Responses

Thioquinoline derivatives conjugated to thiosemicarbazide as potent tyrosinase inhibitors with anti-melanogenesis properties

SYNTHESIS OF SOME NEW UNSYMMETRICAL 1,4-DIHYDROPYRIDINE DERIVATIVES AS POTENT ANTITUBERCULAR AGENTS

Thioester derivatives of the natural product psammaplin A as potent histone deacetylase inhibitors

Theoretical investigation and design of some indole derivatives as potent β-glucuronidase inhibitors

Cultural heritage institutions wishing to register will find more information here.

Fields marked * need to be filled in.

Username*

Please enter your username

Email*

Please enter your email address

Please do not fill this field

First name

Last name

Password*

Please enter your password

Confirm password*

Please enter the same password

I have read the terms of use and the privacy policy for the collection of personal data and accept them. *

This field is required.

I would like to subscribe to the newsletter of the Deutsche Digitale Bibliothek. See newsletter subscription info.

Account created

Your "My DDB" account has been successfully created. Before you can log in to your account, you must click the confirmation link in the message we just sent to the email address you provided.

Lipidic Aminoglycoside Derivatives: A New Class of Immunomodulators Inducing a Potent Innate Immune Stimulation

Object Details

References and Relationships

Contributors, Places and Time

Further information

Data provider

Associated

Other Objects (12)

Anticancer Aminoferrocene Derivatives Inducing Production of Mitochondrial Reactive Oxygen Species

Cigarette smoke aggravates asthma by inducing memory-like type 3 innate lymphoid cells

ERPs in an oddball task under vection-inducing visual stimulation

Coumarin linked to 2-phenylbenzimidazole derivatives as potent α-glucosidase inhibitors

Docking studies of flavonoid derivatives as potent HIV-1 integrase inhibitors

A new approach of inducing proprioceptive illusion by transcutaneous electrical stimulation

Discovery of Novel N-Acylhydrazone Derivatives as Potent Inhibitors of Sirtuin-1

Investigating the Effects of Chronic Stimulation of Innate Antiviral Immune Responses

Thioquinoline derivatives conjugated to thiosemicarbazide as potent tyrosinase inhibitors with anti-melanogenesis properties

SYNTHESIS OF SOME NEW UNSYMMETRICAL 1,4-DIHYDROPYRIDINE DERIVATIVES AS POTENT ANTITUBERCULAR AGENTS

Thioester derivatives of the natural product psammaplin A as potent histone deacetylase inhibitors

Theoretical investigation and design of some indole derivatives as potent β-glucuronidase inhibitors

Anticancer Aminoferrocene Derivatives Inducing Production of Mitochondrial Reactive Oxygen Species

Cigarette smoke aggravates asthma by inducing memory-like type 3 innate lymphoid cells

ERPs in an oddball task under vection-inducing visual stimulation

Coumarin linked to 2-phenylbenzimidazole derivatives as potent α-glucosidase inhibitors

Docking studies of flavonoid derivatives as potent HIV-1 integrase inhibitors

A new approach of inducing proprioceptive illusion by transcutaneous electrical stimulation

Discovery of Novel N-Acylhydrazone Derivatives as Potent Inhibitors of Sirtuin-1

Investigating the Effects of Chronic Stimulation of Innate Antiviral Immune Responses

Thioquinoline derivatives conjugated to thiosemicarbazide as potent tyrosinase inhibitors with anti-melanogenesis properties

SYNTHESIS OF SOME NEW UNSYMMETRICAL 1,4-DIHYDROPYRIDINE DERIVATIVES AS POTENT ANTITUBERCULAR AGENTS

Thioester derivatives of the natural product psammaplin A as potent histone deacetylase inhibitors

Theoretical investigation and design of some indole derivatives as potent β-glucuronidase inhibitors

Anticancer Aminoferrocene Derivatives Inducing Production of Mitochondrial Reactive Oxygen Species

Cigarette smoke aggravates asthma by inducing memory-like type 3 innate lymphoid cells

ERPs in an oddball task under vection-inducing visual stimulation

Coumarin linked to 2-phenylbenzimidazole derivatives as potent α-glucosidase inhibitors

Docking studies of flavonoid derivatives as potent HIV-1 integrase inhibitors

A new approach of inducing proprioceptive illusion by transcutaneous electrical stimulation

Discovery of Novel N-Acylhydrazone Derivatives as Potent Inhibitors of Sirtuin-1

Investigating the Effects of Chronic Stimulation of Innate Antiviral Immune Responses

Thioquinoline derivatives conjugated to thiosemicarbazide as potent tyrosinase inhibitors with anti-melanogenesis properties

SYNTHESIS OF SOME NEW UNSYMMETRICAL 1,4-DIHYDROPYRIDINE DERIVATIVES AS POTENT ANTITUBERCULAR AGENTS

Thioester derivatives of the natural product psammaplin A as potent histone deacetylase inhibitors

Theoretical investigation and design of some indole derivatives as potent β-glucuronidase inhibitors

Related objects

Reset password