Cinnamaldehyde Ameliorates Diet-Induced Obesity in Mice by Inducing Browning of White Adipose Tissue

Abstract: Background/Aims: Obesity has become a major health concern with few effective medications. Cinnamaldehyde (CA) has been reported to exhibit anti-diabetic and anti-inflammatory properties. However, whether CA shows anti-obesity activity remains unknown. Therefore, the present study aimed to investigate the potential anti-obesity effects of CA on mice fed a high-fat diet (HFD) and to explore the possible mechanisms involved. Methods: Male C57BL/6J mice fed an HFD for 12 weeks were supplemented with CA (40 mg/kg/day) via gavage for an additional 8 weeks. Mice fed a standard diet were used as normal controls. Results: The results revealed that CA treatment decreased body weight, fat mass, food intake, and serum lipid, free fatty acid and leptin levels. CA administration also improved insulin sensitivity in HFD-induced obese mice. Additionally, CA inhibited the hypertrophy of adipose tissue and induced browning of white adipose tissue. Uncoupling protein 1 (UCP1) was expressed in white adipose tissue after the oral administration of CA. Furthermore, CA enhanced the expression of the peroxisome proliferator-activated receptor γ (PPARγ), PR domain-containing 16 (PRDM16) and PPARγ coactivator 1α (PGC-1α) proteins in both brown and white adipose tissues. Conclusions: The results suggest that CA exhibits therapeutic potency against obesity by inducing the browning of white adipose tissue in HFD-fed mice.

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• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Cinnamaldehyde Ameliorates Diet-Induced Obesity in Mice by Inducing Browning of White Adipose Tissue ; volume:42 ; number:4 ; year:2017 ; pages:1514-1525 ; extent:12 ; Cellular physiology and biochemistry ; 42, Heft 4 (2017), 1514-1525 (gesamt 12)

Contributors, Places and Time

• Creator: Zuo, Jiacheng ; Zhao, Dandan ; Yu, Na ; Fang, Xin ; Mu, Qianqian ; Ma, Yue ; Mo, Fangfang ; Wu, Rui ; Ma, Rufeng ; Wang, Lili ; Zhu, Ruyuan ; Liu, Haixia ; Zhang, Dongwei ; Gao, Sihua

Further information

• DOI: 10.1159/000479268
• URN: urn:nbn:de:101:1-2404250042404.862051335124
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.