Design, Synthesis and Biological Evaluation of Highly Potent Simplified Archazolids
Abstract: The archazolids are potent antiproliferative compounds that have recently emerged as a novel class of promising anticancer agents. Their complex macrolide structures and scarce natural supply make the development of more readily available analogues highly important. Herein, we report the design, synthesis and biological evaluation of four simplified and partially saturated archazolid derivatives. We also reveal important structure‐activity relationship data as well as insights into the pharmacophore of these complex polyketides.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Design, Synthesis and Biological Evaluation of Highly Potent Simplified Archazolids ; volume:15 ; number:14 ; year:2020 ; pages:1348-1363 ; extent:16
ChemMedChem ; 15, Heft 14 (2020), 1348-1363 (gesamt 16)
- Creator
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Rivière, Solenne
Vielmuth, Christin
Ennenbach, Christiane
Abdelrahman, Aliaa
Lemke, Carina
Gütschow, Michael
Müller, Christa E.
Menche, Dirk
- DOI
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10.1002/cmdc.202000154
- URN
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urn:nbn:de:101:1-2022070311191394983553
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:33 AM CEST
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Associated
- Rivière, Solenne
- Vielmuth, Christin
- Ennenbach, Christiane
- Abdelrahman, Aliaa
- Lemke, Carina
- Gütschow, Michael
- Müller, Christa E.
- Menche, Dirk
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