Hybrid Poly (β ‐amino ester) Triblock Copolymers Utilizing a RAFT Polymerization Grafting‐From Methodology
Abstract: The biocompatibility, biodegradability, and responsiveness of poly (β‐amino esters) (PBAEs) has led to their widespread use as biomaterials for drug and gene delivery. Nonetheless, the step‐growth polymerization mechanism that yields PBAEs limits the scope for their structural optimization toward specific applications because of limited monomer choice and end‐group modifications. Moreover, to date the post‐synthetic functionalization of PBAEs has relied on grafting‐to approaches, challenged by the need for efficient polymer–polymer coupling and potentially difficult post‐conjugation purification. Here a novel grafting‐from approach to grow reversible addition–fragmentation chain transfer (RAFT) polymers from a PBAE scaffold is described. This is achieved through PBAE conversion into a macromolecular chain transfer agent through a multistep capping procedure, followed by RAFT polymerization with a range of monomers to produce PBAE–RAFT hybrid triblock copolymers. Following successful synthesis, the potential biological applications of these ABA triblock copolymers are illustrated through assembly into polymeric micelles and encapsulation of a model hydrophobic drug, followed by successful nanoparticle (NP) uptake in breast cancer cells. The findings demonstrate this novel synthetic methodology can expand the scope of PBAEs as biomaterials.
- Location
-
Deutsche Nationalbibliothek Frankfurt am Main
- Extent
-
Online-Ressource
- Language
-
Englisch
- Bibliographic citation
-
Hybrid Poly (β ‐amino ester) Triblock Copolymers Utilizing a RAFT Polymerization Grafting‐From Methodology ; day:07 ; month:11 ; year:2023 ; extent:11
Macromolecular chemistry and physics ; (07.11.2023) (gesamt 11)
- Creator
-
Kasza, Karolina
Elsherbeny, Amr
Moloney, Cara
Hardie, Kim R.
Cámara, Miguel
Alexander, Cameron
Gurnani, Pratik
- DOI
-
10.1002/macp.202300262
- URN
-
urn:nbn:de:101:1-2023110814070761496830
- Rights
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
-
14.08.2025, 10:44 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Kasza, Karolina
- Elsherbeny, Amr
- Moloney, Cara
- Hardie, Kim R.
- Cámara, Miguel
- Alexander, Cameron
- Gurnani, Pratik
Other Objects (12)
Functional PLA based (co)polymers via ROP and RAFT polymerization
Synthetic routes toward functional block copolymers and bioconjugates via RAFT polymerization
Synthetic routes toward functional block copolymers and bioconjugates via RAFT polymerization
RAFT polymerization-induced self-assembly of semifluorinated liquid-crystalline block copolymers
Self-assembly of block copolymers synthesized via RAFT emulsion and dispersion polymerization
Non-ionic amphiphilic block copolymers by RAFT-polymerization and their self-organization
Nonionic UCST–LCST Diblock Copolymers with Tunable Thermoresponsiveness Synthesized via PhotoRAFT Polymerization
Novel amphiphilic diblock copolymers by RAFT-polymerization, their self-organization and surfactant properties
RAFT polymerization, Volume 2
Handbook of RAFT polymerization
RAFT polymerization, Volume 1
Photo‐Iniferter RAFT Polymerization
Functional PLA based (co)polymers via ROP and RAFT polymerization
Synthetic routes toward functional block copolymers and bioconjugates via RAFT polymerization
Synthetic routes toward functional block copolymers and bioconjugates via RAFT polymerization
RAFT polymerization-induced self-assembly of semifluorinated liquid-crystalline block copolymers
Self-assembly of block copolymers synthesized via RAFT emulsion and dispersion polymerization
Non-ionic amphiphilic block copolymers by RAFT-polymerization and their self-organization
Nonionic UCST–LCST Diblock Copolymers with Tunable Thermoresponsiveness Synthesized via PhotoRAFT Polymerization
Novel amphiphilic diblock copolymers by RAFT-polymerization, their self-organization and surfactant properties
RAFT polymerization, Volume 2
Handbook of RAFT polymerization
RAFT polymerization, Volume 1
Photo‐Iniferter RAFT Polymerization
Functional PLA based (co)polymers via ROP and RAFT polymerization
Synthetic routes toward functional block copolymers and bioconjugates via RAFT polymerization
Synthetic routes toward functional block copolymers and bioconjugates via RAFT polymerization
RAFT polymerization-induced self-assembly of semifluorinated liquid-crystalline block copolymers
Self-assembly of block copolymers synthesized via RAFT emulsion and dispersion polymerization
Non-ionic amphiphilic block copolymers by RAFT-polymerization and their self-organization
Nonionic UCST–LCST Diblock Copolymers with Tunable Thermoresponsiveness Synthesized via PhotoRAFT Polymerization
Novel amphiphilic diblock copolymers by RAFT-polymerization, their self-organization and surfactant properties
RAFT polymerization, Volume 2
Handbook of RAFT polymerization
RAFT polymerization, Volume 1