Photocatalytic Carbon Dots‐Triggered Pyroptosis for Whole Cancer Cell Vaccines
Abstract: Manufacturing whole cancer cell vaccines (WCCV) with both biosafety and efficacy is crucial for tumor immunotherapy. Pyroptotic cancer cells, due to their highly immunogenic properties, present a promising avenue for the development of WCCV. However, the successful development of WCCV based on pyroptotic cancer cells is yet to be accomplished. Here, a facile strategy that utilized photocatalytic carbon dots (CDs) to induce pyroptosis of cancer cells for fabricating WCCV is reported. Photocatalytic CDs are capable of generating substantial amounts of hydroxyl radicals and can effectively decrease cytoplasmic pH values under white light irradiation. This process efficiently triggers cancer cell pyroptosis through the reactive oxygen species (ROS)‐mitochondria‐caspase 3‐gasdermin E pathway and the proton motive force‐driven mitochondrial ATP synthesis pathway. Moreover, in vitro, these photocatalytic CDs‐induced pyroptotic cancer cells (PCIP) can hyperactivate macrophage (M0–M1) with upregulation of major histocompatibility complex class II expression. In vivo, PCIP induced specific immune‐preventive effects in melanoma and breast cancer mouse models through anticancer immune memory, demonstrating effective WCCV. This work provides novel insights for inducing cancer cell pyroptosis and bridges the gap in the fabrication of WCCV based on pyroptotic cancer cells.
- Location
-
Deutsche Nationalbibliothek Frankfurt am Main
- Extent
-
Online-Ressource
- Language
-
Englisch
- Bibliographic citation
-
Photocatalytic Carbon Dots‐Triggered Pyroptosis for Whole Cancer Cell Vaccines ; day:12 ; month:08 ; year:2024 ; extent:12
Advanced materials ; (12.08.2024) (gesamt 12)
- Creator
-
Cheng, Quansheng
Zhang, Tesen
Wang, Qingcheng
Wu, Xue
Li, Lingyun
Lin, Runxing
Zhou, Yinning
Qu, Songnan
- DOI
-
10.1002/adma.202408685
- URN
-
urn:nbn:de:101:1-2408121415343.200997159148
- Rights
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
-
14.08.2025, 10:48 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Cheng, Quansheng
- Zhang, Tesen
- Wang, Qingcheng
- Wu, Xue
- Li, Lingyun
- Lin, Runxing
- Zhou, Yinning
- Qu, Songnan
Other Objects (12)
Profiling stress-triggered RNA condensation with photocatalytic proximity labeling
Carbon Dots for Photocatalytic Degradation of Aqueous Pollutants: Recent Advancements
Emerging Opportunities of Colloidal Quantum Dots for Photocatalytic Organic Transformations
Photocatalytic Pt (IV)‐Coordinated Carbon Dots for Precision Tumor Therapy
Mild endoplasmic reticulum stress alleviates FB1-triggered intestinal pyroptosis via the Sec62-PERK pathway
Coherent phonons in CdSe quantum dots triggered by ultrafast electron transfer
CdSe quantum dotsZIF-8 : hybrid materials with improved photocatalytic efficiency
Photocatalytic CO 2 Reduction Using Homogeneous Carbon Dots with a Molecular Cobalt Catalyst
Evaluating carbon dots as electron mediators in photochemical and photocatalytic processes of NiFe2O4
Facile One-Step Sonochemical Synthesis and Photocatalytic Properties of Graphene/Ag3PO4 Quantum Dots Composites
Coupling of BiOCl Ultrathin Nanosheets with Carbon Quantum Dots for Enhanced Photocatalytic Performance
Aerobic Conditions Enhance the Photocatalytic Stability of CdS/CdO x Quantum Dots
Profiling stress-triggered RNA condensation with photocatalytic proximity labeling
Carbon Dots for Photocatalytic Degradation of Aqueous Pollutants: Recent Advancements
Emerging Opportunities of Colloidal Quantum Dots for Photocatalytic Organic Transformations
Photocatalytic Pt (IV)‐Coordinated Carbon Dots for Precision Tumor Therapy
Mild endoplasmic reticulum stress alleviates FB1-triggered intestinal pyroptosis via the Sec62-PERK pathway
Coherent phonons in CdSe quantum dots triggered by ultrafast electron transfer
CdSe quantum dotsZIF-8 : hybrid materials with improved photocatalytic efficiency
Photocatalytic CO 2 Reduction Using Homogeneous Carbon Dots with a Molecular Cobalt Catalyst
Evaluating carbon dots as electron mediators in photochemical and photocatalytic processes of NiFe2O4
Facile One-Step Sonochemical Synthesis and Photocatalytic Properties of Graphene/Ag3PO4 Quantum Dots Composites
Coupling of BiOCl Ultrathin Nanosheets with Carbon Quantum Dots for Enhanced Photocatalytic Performance
Aerobic Conditions Enhance the Photocatalytic Stability of CdS/CdO x Quantum Dots
Profiling stress-triggered RNA condensation with photocatalytic proximity labeling
Carbon Dots for Photocatalytic Degradation of Aqueous Pollutants: Recent Advancements
Emerging Opportunities of Colloidal Quantum Dots for Photocatalytic Organic Transformations
Photocatalytic Pt (IV)‐Coordinated Carbon Dots for Precision Tumor Therapy
Mild endoplasmic reticulum stress alleviates FB1-triggered intestinal pyroptosis via the Sec62-PERK pathway
Coherent phonons in CdSe quantum dots triggered by ultrafast electron transfer
CdSe quantum dotsZIF-8 : hybrid materials with improved photocatalytic efficiency
Photocatalytic CO 2 Reduction Using Homogeneous Carbon Dots with a Molecular Cobalt Catalyst
Evaluating carbon dots as electron mediators in photochemical and photocatalytic processes of NiFe2O4
Facile One-Step Sonochemical Synthesis and Photocatalytic Properties of Graphene/Ag3PO4 Quantum Dots Composites
Coupling of BiOCl Ultrathin Nanosheets with Carbon Quantum Dots for Enhanced Photocatalytic Performance