Role of p53 in transcriptional regulation of proteases in mammals.
Abstract: p53, besides being a tumor suppressor protein, is a transcription factor with a powerful activation domain. Mutation (s) in this gene is a frequent event in human carcinogenesis. Several of these mutations lead to loss of its function as transcription factor. Proteases are thought to play an important role in tumor invasion and metastasis by degradation of extra cellular matrices and basement membranes. The function of protein-coding genes is carried out by the protein product, it is important to study p53-dependent expression at the protein level. There are many factors which regulate the expression of proteases in the cell, however here in this review we have focused on the p53 gene and its regulatory effect on the expression of proteases.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Role of p53 in transcriptional regulation of proteases in mammals. ; volume:29 ; number:04 ; year:2008 ; pages:19-22
Indian journal of medical & paediatric oncology ; 29, Heft 04 (2008), 19-22
- Contributor
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Katara, Rahul
Singh, N.
- DOI
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10.4103/0971-5851.51400
- URN
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urn:nbn:de:101:1-2022031216502488658950
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:31 AM CEST
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Associated
- Katara, Rahul
- Singh, N.
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NGF-mediated transcriptional targets of p53 in PC12 neuronal differentiation
Interaction of p53 with the Δ133p53α and Δ160p53α isoforms regulates p53 conformation and transcriptional activity
Comparative genomic analysis of the zebra finch degradome provides new insights into evolution of proteases in birds and mammals
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Reversible inactivation of the transcriptional function of P53 protein by farnesylation
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