Exercise, CaMKII, and type 2 diabetes
Abstract: Individuals who exercise regularly are protected from type 2 diabetes and other metabolic syndromes, in part by enhanced gene transcription and induction of many signaling pathways crucial in correcting impaired metabolic pathways associated with a sedentary lifestyle. Exercise activates Calmodulin-dependent protein kinase (CaMK)II, resulting in increased mitochondrial oxidative capacity and glucose transport. CaMKII regulates many health beneficial cellular functions in individuals who exercise compared with those who do not exercise. The role of exercise in the regulation of carbohydrate, lipid metabolism, and insulin signaling pathways are explained at the onset. Followed by the role of exercise in the regulation of glucose transporter (GLUT)4 expression and mitochondrial biogenesis are explained. Next, the main functions of Calmodulin-dependent protein kinase and the mechanism to activate it are illustrated, finally, an overview of the role of CaMKII in regulating GLUT4 express.... https://www.excli.de/index.php/excli/article/view/3317
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Exercise, CaMKII, and type 2 diabetes ; volume:20 ; day:17 ; month:02 ; year:2021
EXCLI journal ; 20 (17.02.2021)
- Creator
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Joseph, Jitcy S.
Anand, Krishnan
Malindisa, Sibusiso T.
Oladipo, Adewale O.
Fagbohun, Oladapo F.
- DOI
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10.17179/excli2020-3317
- URN
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urn:nbn:de:101:1-2021051813381227330252
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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14.08.2025, 10:52 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Joseph, Jitcy S.
- Anand, Krishnan
- Malindisa, Sibusiso T.
- Oladipo, Adewale O.
- Fagbohun, Oladapo F.
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