Application of Transaminases in a Disperse System for the Bioamination of Hydrophobic Substrates

Abstract: The challenging bioamination of hydrophobic substrates has been attained through the employment of a disperse system consisting of a combination of a low polarity solvent (e. g. isooctane or methyl‐tert‐butylether), a non‐ionic surfactant and a minimal amount of water. In these conditions, amine transaminases (ATA) were shown to efficiently carry out the reductive amination of variously substituted cyclohexanones, providing good conversions often coupled with a superior stereoselectivity if compared with the corresponding chemical reductive amination. An array of synthetically useful 4‐substituted aminocyclohexanes was consequentially synthesized through biocatalysis, analyzed and stereochemically characterized.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Application of Transaminases in a Disperse System for the Bioamination of Hydrophobic Substrates ; volume:362 ; number:5 ; year:2020 ; pages:1156-1166 ; extent:11 ; Advanced synthesis & catalysis ; 362, Heft 5 (2020), 1156-1166 (gesamt 11)

Contributors, Places and Time

• Creator: Fiorati, Andrea ; Berglund, Per ; Humble, Maria S. ; Tessaro, Davide

Further information

• DOI: 10.1002/adsc.201901434
• URN: urn:nbn:de:101:1-2022060614142184892959
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 15.08.2025, 7:37 AM CEST