Antibiotic use in pediatric acute care hospitals: an analysis of antibiotic consumption data from Germany, 2013–2020
Abstract: Background
Antimicrobial stewardship (AMS) programs are effective tools for improving antibiotic prescription quality. Their implementation requires the regular surveillance of antibiotic consumption at the patient and institutional level. Our study captured and analyzed antibiotic consumption density (ACD) for hospitalized pediatric patients.
Method
We collected antibacterial drug consumption data for 2020 from hospital pharmacies at 113 pediatric departments of acute care hospitals in Germany. ACD was calculated as defined daily dose (DDD, WHO/ATC Index 2019) per 100 patient days (pd). In addition, we analyzed the trends in antibiotic use during 2013–2020.
Results
In 2020, median ACD across all participating hospitals was 26.7 DDD/100 pd, (range: 10.1–79.2 DDD/100 pd). It was higher at university vs. non-university hospitals (38.6 vs. 25.2 DDD/100 pd, p < 0.0001). The highest use densities were seen on oncology wards and intensive care units at university hospitals (67.3 vs. 38.4 DDD/100 pd). During 2013–2020, overall ACD declined (− 10%) and cephalosporin prescriptions also decreased (− 36%). In 2020, cephalosporins nevertheless remained the most commonly dispensed class of antibiotics. Interhospital variability in cephalosporin/penicillin ratio was substantial. Antibiotics belonging to WHO AWaRe “Watch” and “Reserve” categories, including broad-spectrum penicillins (+ 31%), linezolid (+ 121%), and glycopeptides (+ 43%), increased over time.
Conclusion
Significant heterogeneity in ACD and prescription of different antibiotic classes as well as high prescription rates for cephalosporins and an increased use of reserve antibiotics indicate improvable antibiotic prescribing quality. AMS programs should urgently prioritize these issues to reduce antimicrobial resistance
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Notes
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Infection. - 52, 3 (2024) , 825-837, ISSN: 1439-0973
- Event
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Veröffentlichung
- (where)
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Freiburg
- (who)
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Universität
- (when)
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2023
- Creator
- DOI
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10.1007/s15010-023-02112-w
- URN
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urn:nbn:de:bsz:25-freidok-2408778
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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14.08.2025, 10:56 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Freudenhammer, Mirjam
- Hufnagel, Markus
- Steib-Bauert, Michaela
- Mansmann, Ulrich
- With, Katja de
- Fellhauer, Matthias
- Kern, Winfried V.
- Universität
Time of origin
- 2023
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Impact of the COVID-19 pandemic on inpatient antibiotic and antifungal drug prescribing volumes in Germany
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Antibiotic use in pediatric acute care hospitals: an analysis of antibiotic consumption data from Germany, 2013–2020
Organization of antibiotic stewardship in Europe: the way to go
Prevalence of and factors associated with antibiotic prescriptions in patients with acute lower and upper respiratory tract Infections - a case-control study
Aufnahmeprävalenz und Parallelresistenzen 3. Generations-Cephalosporin-resistenter Enterobacteriaceae
Improving empiric antibiotic prescribing in pediatric bloodstream infections: a potential application of weighted-incidence syndromic combination antibiograms (WISCA)
Klinische Epidemiologie, Serotypenverteilung und Antibiotikaresistenz von Gruppe B Streptokokken (GBS) in der Schwangerschaft : : prospektive Kohortenstudie an der Universitäts-Frauenklinik Freiburg in den Jahren 2009-2010
Vergleich verschiedener In-Vitro-Random-Mutagenese-Methoden zur Generierung einer AcrB-Mutanten-Bibliothek als Basis für ein Screening auf Effluxpumpen-Inhibitor-Resistenz
Vergleichende Untersuchungen zur Empfindlichkeit von Staphylococcus aureus-Kolonisations- und Infektionsisolaten aus Bagamoyo (Tansania) und Freiburg (Deutschland) gegenüber antimikrobiellen Peptiden
Die Eignung von Punkt-Prävalenz-Studien und der Dosisdefinitionen DDD und RDD zur Evaluation des Verbrauchs antimikrobieller Wirkstoffe am Universitätsklinikum Freiburg im Breisgau
In-person medical conferences during the COVID-19 pandemic
Impact of the COVID-19 pandemic on inpatient antibiotic and antifungal drug prescribing volumes in Germany
Antimicrobial use in pediatric oncology and hematology in Germany and Austria, 2020/2021: a cross-sectional, multi-center point-prevalence study with a multi-step qualitative adjudication process
Antibiotic use in pediatric acute care hospitals: an analysis of antibiotic consumption data from Germany, 2013–2020
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Prevalence of and factors associated with antibiotic prescriptions in patients with acute lower and upper respiratory tract Infections - a case-control study
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Improving empiric antibiotic prescribing in pediatric bloodstream infections: a potential application of weighted-incidence syndromic combination antibiograms (WISCA)
Klinische Epidemiologie, Serotypenverteilung und Antibiotikaresistenz von Gruppe B Streptokokken (GBS) in der Schwangerschaft : : prospektive Kohortenstudie an der Universitäts-Frauenklinik Freiburg in den Jahren 2009-2010
Vergleich verschiedener In-Vitro-Random-Mutagenese-Methoden zur Generierung einer AcrB-Mutanten-Bibliothek als Basis für ein Screening auf Effluxpumpen-Inhibitor-Resistenz
Vergleichende Untersuchungen zur Empfindlichkeit von Staphylococcus aureus-Kolonisations- und Infektionsisolaten aus Bagamoyo (Tansania) und Freiburg (Deutschland) gegenüber antimikrobiellen Peptiden
Die Eignung von Punkt-Prävalenz-Studien und der Dosisdefinitionen DDD und RDD zur Evaluation des Verbrauchs antimikrobieller Wirkstoffe am Universitätsklinikum Freiburg im Breisgau
In-person medical conferences during the COVID-19 pandemic
Impact of the COVID-19 pandemic on inpatient antibiotic and antifungal drug prescribing volumes in Germany