Deubiquitylating Enzymes in Cancer and Immunity
Abstract: Deubiquitylating enzymes (DUBs) maintain relative homeostasis of the cellular ubiquitome by removing the post‐translational modification ubiquitin moiety from substrates. Numerous DUBs have been demonstrated specificity for cleaving a certain type of ubiquitin linkage or positions within ubiquitin chains. Moreover, several DUBs perform functions through specific protein–protein interactions in a catalytically independent manner, which further expands the versatility and complexity of DUBs’ functions. Dysregulation of DUBs disrupts the dynamic equilibrium of ubiquitome and causes various diseases, especially cancer and immune disorders. This review summarizes the Janus‐faced roles of DUBs in cancer including proteasomal degradation, DNA repair, apoptosis, and tumor metastasis, as well as in immunity involving innate immune receptor signaling and inflammatory and autoimmune disorders. The prospects and challenges for the clinical development of DUB inhibitors are further discussed. The review provides a comprehensive understanding of the multi‐faced roles of DUBs in cancer and immunity.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Deubiquitylating Enzymes in Cancer and Immunity ; day:27 ; month:10 ; year:2023 ; extent:37
Advanced science ; (27.10.2023) (gesamt 37)
- Urheber
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Ren, Jiang
Yu, Peng
Liu, Sijia
Li, Ran
Niu, Xin
Chen, Yan
Zhang, Zhenyu
Zhou, Fangfang
Zhang, Long
- DOI
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10.1002/advs.202303807
- URN
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urn:nbn:de:101:1-2023102715292692680581
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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14.08.2025, 10:44 MESZ
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Ren, Jiang
- Yu, Peng
- Liu, Sijia
- Li, Ran
- Niu, Xin
- Chen, Yan
- Zhang, Zhenyu
- Zhou, Fangfang
- Zhang, Long
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