Expansions, diversification, and interindividual copy number variations of AID/APOBEC family cytidine deaminase genes in lampreys
Abstract: Cytidine deaminases of the AID/APOBEC family mutate the genetic material of pathogens or contribute to the generation and diversification of antibody repertoires in jawed vertebrates. In the extant jawless vertebrate, the lamprey, two members of the AID/APOBEC family are implicated in the somatic diversification of variable lymphocyte receptor (VLR) repertoires. We discovered an unexpected diversity of cytidine deaminase genes within and among lamprey species. The cytidine deaminases with features comparable to jawed vertebrate AID are always present, suggesting that they are involved in essential processes, such as VLR assembly. In contrast, other genes show a remarkable copy number variation, like the APOBEC3 genes in mammals. This suggests an unexpected similarity in functional deployment of AID/APOBEC cytidine deaminases across all vertebrates
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Anmerkungen
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Proceedings of the National Academy of Sciences of the United States of America. - 115, 14 (2018) , E3211-E3220, ISSN: 0027-8424
- Ereignis
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Veröffentlichung
- (wo)
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Freiburg
- (wer)
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Universität
- (wann)
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2019
- Urheber
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Holland, Stephen J.
Berghuis, Lesley M.
King, Justin J.
Iyer, Lakshminarayan M.
Sikora, Katarzyna
Fifield, Heather
Peter, Sarah
Quinlan, Emma M.
Sugahara, Fumiaki
Shingate, Prashant
Trancoso, Inês
Iwanami, Norimasa
Temereva, Elena
Strohmeier, Christine
Kuratani, Shigeru
Venkatesh, Byrappa
Evanno, Guillaume
Aravind, L.
Schorpp, Michael
Larijani, Mani
Boehm, Thomas
- Beteiligte Personen und Organisationen
- DOI
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10.1073/pnas.1720871115
- URN
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urn:nbn:de:bsz:25-freidok-1479650
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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25.03.2025, 13:49 MEZ
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Beteiligte
- Holland, Stephen J.
- Berghuis, Lesley M.
- King, Justin J.
- Iyer, Lakshminarayan M.
- Sikora, Katarzyna
- Fifield, Heather
- Peter, Sarah
- Quinlan, Emma M.
- Sugahara, Fumiaki
- Shingate, Prashant
- Trancoso, Inês
- Iwanami, Norimasa
- Temereva, Elena
- Strohmeier, Christine
- Kuratani, Shigeru
- Venkatesh, Byrappa
- Evanno, Guillaume
- Aravind, L.
- Schorpp, Michael
- Larijani, Mani
- Boehm, Thomas
- Max-Planck-Institut für Immunbiologie
- Universität
Entstanden
- 2019
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