Drug‐Loaded Mucoadhesive Patch with Active Delivery and Controlled Releasing Ability
Herein, a mucoadhesive patch for gastrointestinal tracts with active delivery, hyperthermia, and controlled drug release function using a magnetically actuated capsule is proposed to overcome the drug delivery and efficiency challenges of wireless structures. The proposed patch has excellent adhesion to the gastrointestinal tract and contains anticancer drug doxorubicin and magnetic nanoparticles. This enables hyperthermia and the controlled release of the loaded drug under an alternating magnetic field (AMF). In addition, it can be delivered to multiple intestinal target lesions using a magnetically actuated capsule. Characteristic analyses of the proposed patch are performed, such as morphology, adhesion force measurement with intestine, temperature change under an AMF, and drug release. The feasibility of the patch delivery into the gastrointestinal tract is verified through locomotion performance tests and ex vivo patch delivery experiments using a magnetically actuated capsule. Finally, through an in vitro therapeutic effect test, the death of tumor cells using the proposed patch is confirmed. As a result, the possibility that the multiple mucoadhesive patches can be delivered to target lesions in a digestive tract through a magnetically actuated capsule and can treat the lesions through hyperthermia and active drug release using an AMF stimulation is verified.
- Standort
-
Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
-
Online-Ressource
- Sprache
-
Englisch
- Erschienen in
-
Drug‐Loaded Mucoadhesive Patch with Active Delivery and Controlled Releasing Ability ; day:19 ; month:01 ; year:2022 ; extent:10
Advanced intelligent systems ; (19.01.2022) (gesamt 10)
- Urheber
-
Lee, Jihun
Kim, Dong-in
Bang, Seungmin
Park, Sukho
- DOI
-
10.1002/aisy.202100203
- URN
-
urn:nbn:de:101:1-2022011914161615493487
- Rechteinformation
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
-
15.08.2025, 07:33 MESZ
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Lee, Jihun
- Kim, Dong-in
- Bang, Seungmin
- Park, Sukho
Ähnliche Objekte (12)
Drug‐Loaded Mucoadhesive Patch with Active Delivery and Controlled Releasing Ability
NHS-POx-loaded patch versus fibrin sealant patch in a porcine robotic liver bleeding model
Primaquine-loaded transdermal patch for treating malaria: design, development, and characterization
Pharmacodynamic Studies of Pravastatin Sodium Nanoemulsion Loaded Transdermal Patch for Treatment of Hyperlipidemia
An electrospun protein-and chromophore-loaded patch : application to laser-assisted vascular anastomosis
Patient Perceptions and Preferences for a Mealtime Insulin Delivery Patch
A Conformable Ultrasound Patch for Cavitation‐Enhanced Transdermal Cosmeceutical Delivery
Smartphone-powered iontophoresis-microneedle array patch for controlled transdermal delivery
Epitope-loaded nanoemulsion delivery system with ability of extending antigen release elicits potent Th1 response for intranasal vaccine against Helicobacter pylori
Implantable Patch of Oxidized Nanofibrillated Cellulose and Lysozyme Amyloid Nanofibrils for the Regeneration of Infarcted Myocardium Tissue and Local Delivery of RNA‐Loaded Nanoparticles
Hydroxycamptothecin-loaded nanoparticles enhance target drug delivery and anticancer effect
Novel drug-loaded paper tablets for improved oral drug delivery
Drug‐Loaded Mucoadhesive Patch with Active Delivery and Controlled Releasing Ability
NHS-POx-loaded patch versus fibrin sealant patch in a porcine robotic liver bleeding model
Primaquine-loaded transdermal patch for treating malaria: design, development, and characterization
Pharmacodynamic Studies of Pravastatin Sodium Nanoemulsion Loaded Transdermal Patch for Treatment of Hyperlipidemia
An electrospun protein-and chromophore-loaded patch : application to laser-assisted vascular anastomosis
Patient Perceptions and Preferences for a Mealtime Insulin Delivery Patch
A Conformable Ultrasound Patch for Cavitation‐Enhanced Transdermal Cosmeceutical Delivery
Smartphone-powered iontophoresis-microneedle array patch for controlled transdermal delivery
Epitope-loaded nanoemulsion delivery system with ability of extending antigen release elicits potent Th1 response for intranasal vaccine against Helicobacter pylori
Implantable Patch of Oxidized Nanofibrillated Cellulose and Lysozyme Amyloid Nanofibrils for the Regeneration of Infarcted Myocardium Tissue and Local Delivery of RNA‐Loaded Nanoparticles
Hydroxycamptothecin-loaded nanoparticles enhance target drug delivery and anticancer effect
Novel drug-loaded paper tablets for improved oral drug delivery
Drug‐Loaded Mucoadhesive Patch with Active Delivery and Controlled Releasing Ability
NHS-POx-loaded patch versus fibrin sealant patch in a porcine robotic liver bleeding model
Primaquine-loaded transdermal patch for treating malaria: design, development, and characterization
Pharmacodynamic Studies of Pravastatin Sodium Nanoemulsion Loaded Transdermal Patch for Treatment of Hyperlipidemia
An electrospun protein-and chromophore-loaded patch : application to laser-assisted vascular anastomosis
Patient Perceptions and Preferences for a Mealtime Insulin Delivery Patch
A Conformable Ultrasound Patch for Cavitation‐Enhanced Transdermal Cosmeceutical Delivery
Smartphone-powered iontophoresis-microneedle array patch for controlled transdermal delivery
Epitope-loaded nanoemulsion delivery system with ability of extending antigen release elicits potent Th1 response for intranasal vaccine against Helicobacter pylori
Implantable Patch of Oxidized Nanofibrillated Cellulose and Lysozyme Amyloid Nanofibrils for the Regeneration of Infarcted Myocardium Tissue and Local Delivery of RNA‐Loaded Nanoparticles
Hydroxycamptothecin-loaded nanoparticles enhance target drug delivery and anticancer effect