A Homogeneous Nickel Catalyst for Reductive Amination of γ‐Keto Acids using Hydrogen
Abstract: The reductive amination of levulinic and 2‐acetyl benzoic acids with hydrogen and various amines proceeds efficiently in the presence of a homogeneous Ni/triphos‐catalyst. The reaction rate of the overall process is significantly enhanced using 3,3,3‐trifluoroethanol (TFE) as solvent. The optimized synthetic protocol allows for a straightforward access of >20 examples of N‐functionalized pyrrolidinones in high yields (75 % and >99 %). Upscaling to 10 mmol‐scale is demonstrated and mechanistic in situ studies revealed the presence of alkoxy‐ and hydroxylactams as crucial intermediates.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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A Homogeneous Nickel Catalyst for Reductive Amination of γ‐Keto Acids using Hydrogen ; day:26 ; month:09 ; year:2024 ; extent:8
ChemCatChem ; (26.09.2024) (gesamt 8)
- Creator
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Chakrabortty, Soumyadeep
Moritz, Jan‐Ole
Kallmeier, Fabian
Neumann, Helfried
Tin, Sergey
Beller, Matthias
Vries, Johannes G. de
- DOI
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10.1002/cctc.202400987
- URN
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urn:nbn:de:101:1-2409271404339.781638868293
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:23 AM CEST
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Associated
- Chakrabortty, Soumyadeep
- Moritz, Jan‐Ole
- Kallmeier, Fabian
- Neumann, Helfried
- Tin, Sergey
- Beller, Matthias
- Vries, Johannes G. de
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