Microvessel density as a prognostic indicator of prostate cancer: A systematic review and meta-analysis
Abstract: The aim of this study is to evaluate prognostic and therapeutic implications of microvessel density (MVD) in the recurrence-free survival (RFS), disease-specific survival (DSS), and overall survival (OS) in prostate cancer (PCa). As of April 2019, EMBASE, PubMed, Cochrane Library, Science Direct/Elsevier, MEDLINE, and CNKI are used for systematic literature retrieval to investigate the correlation between MVD and PCa. Meta-analysis was performed using Review Manager and Stata software. Combined hazard ratio (HR) was identified with 95% confidence intervals (95% CI) in a random or fixed effects model. Thirteen studies were identified in this article. Of which, 8 studies analyzed for the recurrence-free survival (2,399 patients) demonstrated that MVD significantly elevated in the poor recurrence-free survival (HR 2.57, 95% CI 2.21–2.97). Other 2 eligible studies (330 patients) with 3 data sets for the MVD-OS analysis and the pooled HR (HR 1.70, 95% CI 1.27–2.28) suggested a weak risk of overall death rate in patients with high-MVD levels. The last 3 studies for disease-specific survival (220 patients) suggested that the association with high MVD and disease-specific survival may not have statistically significance (HR 1.32, 95% CI 0.49–3.56). This study suggests that high intratumoral MVD appears a significant progenitor for poor recurrence-free survival of PCa.
- Standort
-
Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
-
Online-Ressource
- Sprache
-
Englisch
- Erschienen in
-
Microvessel density as a prognostic indicator of prostate cancer: A systematic review and meta-analysis ; volume:16 ; number:1 ; year:2021 ; pages:882-891 ; extent:10
Open medicine ; 16, Heft 1 (2021), 882-891 (gesamt 10)
- Urheber
-
Feng, Guangui
Wang, Kai
Jiang, Zhao
- DOI
-
10.1515/med-2020-0235
- URN
-
urn:nbn:de:101:1-2022092014123271789576
- Rechteinformation
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
-
15.08.2025, 07:29 MESZ
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Feng, Guangui
- Wang, Kai
- Jiang, Zhao
Ähnliche Objekte (12)
Management and prognostic analysis of patients with gestational trophoblastic neoplasia (GTN) in FIGO stage IV and its special type
Towards a taxonomy of idea generation techniques
Die gegenseitigen Entscheidungsfaktoren der Sprachen und der schriftlichen Repräsentation : eine Analyse der Sprach-Schrift-Zusammenhänge bezüglich korrelativen Bestimmungen und Gestaltungen
Independent prognostic importance of the albumin-corrected anion gap in critically ill patients with congestive heart failure: a retrospective study from MIMIC-IV database
Hopf bifurcation of a delayed SIQR epidemic model with constant input and nonlinear incidence rate
Thoughts and exploration of spatial planning system in the new era
Linkage analysis of systolic blood pressure: a score statistic and computer implementation
MOOC-based flipped learning in higher education: students’ participation, experience and learning performance
Bivariate linkage analysis of cholesterol and triglyceride levels in the Framingham Heart Study
Toeplitz Operators on Higher Cauchy–Riemann Spaces Over the Unit Ball
National Spatial Planning in China : Theoretical Approach and Applied Practice
Tissue-wide cell-specific proteogenomic modeling reveals novel candidate risk genes in autism spectrum disorders
Management and prognostic analysis of patients with gestational trophoblastic neoplasia (GTN) in FIGO stage IV and its special type
Towards a taxonomy of idea generation techniques
Die gegenseitigen Entscheidungsfaktoren der Sprachen und der schriftlichen Repräsentation : eine Analyse der Sprach-Schrift-Zusammenhänge bezüglich korrelativen Bestimmungen und Gestaltungen
Independent prognostic importance of the albumin-corrected anion gap in critically ill patients with congestive heart failure: a retrospective study from MIMIC-IV database
Hopf bifurcation of a delayed SIQR epidemic model with constant input and nonlinear incidence rate
Thoughts and exploration of spatial planning system in the new era
Linkage analysis of systolic blood pressure: a score statistic and computer implementation
MOOC-based flipped learning in higher education: students’ participation, experience and learning performance
Bivariate linkage analysis of cholesterol and triglyceride levels in the Framingham Heart Study
Toeplitz Operators on Higher Cauchy–Riemann Spaces Over the Unit Ball
National Spatial Planning in China : Theoretical Approach and Applied Practice
Tissue-wide cell-specific proteogenomic modeling reveals novel candidate risk genes in autism spectrum disorders
Management and prognostic analysis of patients with gestational trophoblastic neoplasia (GTN) in FIGO stage IV and its special type
Towards a taxonomy of idea generation techniques
Die gegenseitigen Entscheidungsfaktoren der Sprachen und der schriftlichen Repräsentation : eine Analyse der Sprach-Schrift-Zusammenhänge bezüglich korrelativen Bestimmungen und Gestaltungen
Independent prognostic importance of the albumin-corrected anion gap in critically ill patients with congestive heart failure: a retrospective study from MIMIC-IV database
Hopf bifurcation of a delayed SIQR epidemic model with constant input and nonlinear incidence rate
Thoughts and exploration of spatial planning system in the new era
Linkage analysis of systolic blood pressure: a score statistic and computer implementation
MOOC-based flipped learning in higher education: students’ participation, experience and learning performance
Bivariate linkage analysis of cholesterol and triglyceride levels in the Framingham Heart Study
Toeplitz Operators on Higher Cauchy–Riemann Spaces Over the Unit Ball
National Spatial Planning in China : Theoretical Approach and Applied Practice