μLED‐based optical cochlear implants for spectrally selective activation of the auditory nerve
Abstract: Electrical cochlear implants (eCIs) partially restore hearing and enable speech comprehension to more than half a million users, thereby re‐connecting deaf patients to the auditory scene surrounding them. Yet, eCIs suffer from limited spectral selectivity, resulting from current spread around each electrode contact and causing poor speech recognition in the presence of background noise. Optogenetic stimulation of the auditory nerve might overcome this limitation as light can be conveniently confined in space. Here, we combined virus‐mediated optogenetic manipulation of cochlear spiral ganglion neurons (SGNs) and microsystems engineering to establish acute multi‐channel optical cochlear implant (oCI) stimulation in adult Mongolian gerbils. oCIs based on 16 microscale thin‐film light‐emitting diodes (μLEDs) evoked tonotopic activation of the auditory pathway with high spectral selectivity and modest power requirements in hearing and deaf gerbils. These results prove the feasibility of μLED‐based oCIs for spectrally selective activation of the auditory nerve.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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μLED‐based optical cochlear implants for spectrally selective activation of the auditory nerve ; volume:12 ; number:8 ; year:2020 ; extent:12
EMBO molecular medicine / European Molecular Biology Organization ; 12, Heft 8 (2020) (gesamt 12)
- Creator
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Dieter, Alexander
Klein, Eric
Keppeler, Daniel
Jablonski, Lukasz
Harczos, Tamas
Hoch, Gerhard
Rankovic, Vladan
Paul, Oliver
Jeschke, Marcus
Ruther, Patrick
Moser, Tobias
- DOI
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10.15252/emmm.202012387
- URN
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urn:nbn:de:101:1-2022070408240627529893
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:35 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Dieter, Alexander
- Klein, Eric
- Keppeler, Daniel
- Jablonski, Lukasz
- Harczos, Tamas
- Hoch, Gerhard
- Rankovic, Vladan
- Paul, Oliver
- Jeschke, Marcus
- Ruther, Patrick
- Moser, Tobias
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Near physiological spectral selectivity of cochlear optogenetics
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Mechanismen der Volumenregulation in Chromaffinzellen des Nebennierenmarks
μLED‐based optical cochlear implants for spectrally selective activation of the auditory nerve
Towards the optical cochlear implant: optogenetic approaches for hearing restoration
A sensory cell diversifies its output by varying Ca 2+ influx‐release coupling among active zones
Quantitative molecular physiology at active zones of calyceal synapses of the auditory pathway
Synaptic physiology of the cochlear sound encoding
Electroretinography and exploration of visual and auditory function in mutant mice with synaptic defects
Molecular physiology of signal transmission along the auditory pathway
Near physiological spectral selectivity of cochlear optogenetics
Struktur und Funktion der afferenten Synapse innerer Haarzellen der Cochlea
Auditory Steady-State Responses (ASSR) und transiente auditorische Hirnstammpotenziale: Evaluation und Hörschwellenvergleich an Mausmodellen der sensorineuralen Schwerhörigkeit
Devising a framework of optogenetic coding in the auditory pathway: insights from auditory midbrain recordings
Mechanismen der Volumenregulation in Chromaffinzellen des Nebennierenmarks
μLED‐based optical cochlear implants for spectrally selective activation of the auditory nerve
Towards the optical cochlear implant: optogenetic approaches for hearing restoration
A sensory cell diversifies its output by varying Ca 2+ influx‐release coupling among active zones
Quantitative molecular physiology at active zones of calyceal synapses of the auditory pathway
Synaptic physiology of the cochlear sound encoding
Electroretinography and exploration of visual and auditory function in mutant mice with synaptic defects
Molecular physiology of signal transmission along the auditory pathway
Near physiological spectral selectivity of cochlear optogenetics
Struktur und Funktion der afferenten Synapse innerer Haarzellen der Cochlea
Auditory Steady-State Responses (ASSR) und transiente auditorische Hirnstammpotenziale: Evaluation und Hörschwellenvergleich an Mausmodellen der sensorineuralen Schwerhörigkeit