Dual‐Responsive Supramolecular Polymeric Nanomedicine for Self‐Cascade Amplified Cancer Immunotherapy
Abstract: Insufficient tumor immunogenicity and immune escape from tumors remain common problems in all tumor immunotherapies. Recent studies have shown that pyroptosis, a form of programmed cell death that is accompanied by immune checkpoint inhibitors, can induce effective immunogenic cell death and long‐term immune activation. Therapeutic strategies to jointly induce pyroptosis and reverse immunosuppressive tumor microenvironments are promising for cancer immunotherapy. In this regard, a dual‐responsive supramolecular polymeric nanomedicine (NCSNPs) to self‐cascade amplify the benefits of cancer immunotherapy is designed. The NCSNPs are formulated by β‐cyclodextrin coupling nitric oxide (NO) donor, a pyroptosis activator, and NLG919, an indoleamine 2,3‐dioxygenase (IDO) inhibitor, and self‐assembled through host–guest molecular recognition and hydrophobic interaction to obtain nanoparticles. NCSNPs possess excellent tumor accumulation and bioavailability attributed to ingenious supramolecular engineering. The study not only confirms the occurrence of NO‐triggered pyroptosis in tumors for the first time but also reverses the immunosuppressive microenvironment in tumor sites via an IDO inhibitor by enhancing the infiltration of cytotoxic T lymphocytes, to achieve remarkable inhibition of tumor proliferation. Thus, this study provides a novel strategy for cancer immunotherapy.
- Location
-
Deutsche Nationalbibliothek Frankfurt am Main
- Extent
-
Online-Ressource
- Language
-
Englisch
- Bibliographic citation
-
Dual‐Responsive Supramolecular Polymeric Nanomedicine for Self‐Cascade Amplified Cancer Immunotherapy ; day:17 ; month:03 ; year:2024 ; extent:12
Advanced science ; (17.03.2024) (gesamt 12)
- Creator
-
Hu, Wenting
Ye, Binglin
Yu, Guocan
Yang, Huang
Wu, Hao
Ding, Yuan
Huang, Feihe
Wang, Weilin
Mao, Zhengwei
- DOI
-
10.1002/advs.202305382
- URN
-
urn:nbn:de:101:1-2024031813112826282701
- Rights
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
-
14.08.2025, 10:47 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Hu, Wenting
- Ye, Binglin
- Yu, Guocan
- Yang, Huang
- Wu, Hao
- Ding, Yuan
- Huang, Feihe
- Wang, Weilin
- Mao, Zhengwei
Other Objects (12)
Secret information security system in computer network based on Bayesian classification and nonlinear algorithm
TNF Receptor Associated Factors
Gevrey smooth topology is proper to detect normalization under Siegel type small divisor conditions
Extraction of knowledge on spatial distribution and spatial relationship from scanned topographic map using Convolutional Neural Networks
Analysis and simulation for an isotropic phase-field model describing grain growth
The term structure of inflation expectations
Application of mechanochemical synthesis of advanced materials
TOAST: improving reference-free cell composition estimation by cross-cell type differential analysis
Accounting for cell type hierarchy in evaluating single cell RNA-seq clustering
Intersections of SLE Paths: the double and cut point dimension of SLE
Topographic analysis supported by a knowledge graph: A case of ridge landscape recognition
On Invariant Tori with Prescribed Frequency in Hamiltonian Systems
Secret information security system in computer network based on Bayesian classification and nonlinear algorithm
TNF Receptor Associated Factors
Gevrey smooth topology is proper to detect normalization under Siegel type small divisor conditions
Extraction of knowledge on spatial distribution and spatial relationship from scanned topographic map using Convolutional Neural Networks
Analysis and simulation for an isotropic phase-field model describing grain growth
The term structure of inflation expectations
Application of mechanochemical synthesis of advanced materials
TOAST: improving reference-free cell composition estimation by cross-cell type differential analysis
Accounting for cell type hierarchy in evaluating single cell RNA-seq clustering
Intersections of SLE Paths: the double and cut point dimension of SLE
Topographic analysis supported by a knowledge graph: A case of ridge landscape recognition
On Invariant Tori with Prescribed Frequency in Hamiltonian Systems
Secret information security system in computer network based on Bayesian classification and nonlinear algorithm
TNF Receptor Associated Factors
Gevrey smooth topology is proper to detect normalization under Siegel type small divisor conditions
Extraction of knowledge on spatial distribution and spatial relationship from scanned topographic map using Convolutional Neural Networks
Analysis and simulation for an isotropic phase-field model describing grain growth
The term structure of inflation expectations
Application of mechanochemical synthesis of advanced materials
TOAST: improving reference-free cell composition estimation by cross-cell type differential analysis
Accounting for cell type hierarchy in evaluating single cell RNA-seq clustering
Intersections of SLE Paths: the double and cut point dimension of SLE
Topographic analysis supported by a knowledge graph: A case of ridge landscape recognition