A Very-Low-Calorie Diet Can Cause Remission of Diabetes Mellitus and Hypertriglyceridemia in Familial Partial Lipodystrophy
There is no strong evidence that any specific diet is the preferred treatment for lipodystrophy syndromes. Here we remark on the benefits of a very-low-calorie diet (VLCD) in a patient with familial partial lipodystrophy type 2 (FPLD2). A 38-year-old female diagnosed with FPLD2, with a history of multiple comorbidities, underwent 16 weeks of VLCD with a short-term goal of improving her metabolic state rapidly to achieve pregnancy by in vitro fertilization (IVF). We observed a reduction of 12.3 kg in body weight and 1.4% in hemoglobin A1c. The decrease in the area under the curves of insulin (−33.2%), triglycerides (−40.7%), and free fatty acids (−34%) were very remarkable. Total body fat was reduced by 16%, and liver fat by 80%. Her egg retrieval rate and quality during IVF were far superior to past hyperstimulation. Our data encourage the use of this medical approach for other patients with similar metabolic and reproductive abnormalities due to adipose tissue insufficiency.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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A Very-Low-Calorie Diet Can Cause Remission of Diabetes Mellitus and Hypertriglyceridemia in Familial Partial Lipodystrophy ; volume:17 ; number:1 ; year:2023 ; pages:103-108 ; extent:6
Obesity facts ; 17, Heft 1 (2023), 103-108 (gesamt 6)
- Creator
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Foss-Freitas, Maria C.
Besci, Özge
Meral, Rasimcan
Neidert, Adam
Chenevert, Thomas L.
Oral, Elif A.
Rothberg, Amy E.
- DOI
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10.1159/000533992
- URN
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urn:nbn:de:101:1-2024021423525179016190
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:37 AM CEST
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Associated
- Foss-Freitas, Maria C.
- Besci, Özge
- Meral, Rasimcan
- Neidert, Adam
- Chenevert, Thomas L.
- Oral, Elif A.
- Rothberg, Amy E.
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Pregnancies Complicated by Familial Hypertriglyceridemia: A Case Report
Heterozygous CAV1 frameshift mutations (MIM 601047) in patients with atypical partial lipodystrophy and hypertriglyceridemia
Anthropometric measurements as a key diagnostic tool for familial partial lipodystrophy in women
Familial partial lipodystrophy type 2 and obesity, two adipose tissue pathologies with different inflammatory profiles
Evaluation of the hypothalamic–pituitary–adrenal axis in a case series of familial partial lipodystrophy
Familial Screening for the Prevention of Rare Diseases: A Focus on Lipodystrophy in Southern Saudi Arabia
The renal manifestations of type 4 familial partial lipodystrophy: a case report and review of literature
Case report: two novel PPARG pathogenic variants associated with type 3 familial partial lipodystrophy in Brazil
Hypertriglyceridemia in Antiretroviral Therapy
Pancreatic fat deposition is increased and related to beta-cell function in women with familial partial lipodystrophy
Peroxisomal proliferator activated receptor-γ deficiency in a Canadian kindred with familial partial lipodystrophy type 3 (FPLD3)
Familial hypertriglyceridemia: an entity with distinguishable features from other causes of hypertriglyceridemia
Pregnancies Complicated by Familial Hypertriglyceridemia: A Case Report
Heterozygous CAV1 frameshift mutations (MIM 601047) in patients with atypical partial lipodystrophy and hypertriglyceridemia
Anthropometric measurements as a key diagnostic tool for familial partial lipodystrophy in women
Familial partial lipodystrophy type 2 and obesity, two adipose tissue pathologies with different inflammatory profiles
Evaluation of the hypothalamic–pituitary–adrenal axis in a case series of familial partial lipodystrophy
Familial Screening for the Prevention of Rare Diseases: A Focus on Lipodystrophy in Southern Saudi Arabia
The renal manifestations of type 4 familial partial lipodystrophy: a case report and review of literature
Case report: two novel PPARG pathogenic variants associated with type 3 familial partial lipodystrophy in Brazil
Hypertriglyceridemia in Antiretroviral Therapy
Pancreatic fat deposition is increased and related to beta-cell function in women with familial partial lipodystrophy