Liver X receptors as regulators of metabolism

Abstract: The liver X receptors (LXR) are crucial regulators of metabolism. After ligand binding, they regulate gene transcription and thereby mediate changes in metabolic pathways. Modulation of LXR and their downstream targets has appeared to be a promising treatment for metabolic diseases especially atherosclerosis and cholesterol metabolism. However, the complexity of LXR action in various metabolic tissues and the liver side effect of LXR activation have slowed down the interest for LXR drugs. In this review, we summarized the role of LXR in the main metabolically active tissues with a special focus on obesity and associated diseases in mammals. We will also discuss the dual interplay between the two LXR isoforms suggesting that they may collaborate to establish a fine and efficient system for the maintenance of metabolism homeostasis.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Liver X receptors as regulators of metabolism ; volume:6 ; number:3 ; year:2015 ; pages:177-190 ; extent:14 ; Biomolecular concepts ; 6, Heft 3 (2015), 177-190 (gesamt 14)

Contributors, Places and Time

• Creator: Korach-André, Marion ; Gustafsson, Jan-Åke

Further information

• DOI: 10.1515/bmc-2015-0007
• URN: urn:nbn:de:101:1-2409241626467.426701118684
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 15.08.2025, 7:33 AM CEST