Photobleaching characteristics of α-(8-quinolinoxy) zinc phthalocyanine, a new type of amphipathic complex
Abstract: The aim of this study was to reveal the photobleaching characteristics of α-(8-quinolinoxy) zinc phthalocyanine (ZnPc-F7), a new type of amphiphilic complex. Normal saline (NS), pure Roswell Park Memorial Institute (RPMI)-1640 medium (1640), RPMI-1640 medium containing 10% fetal calf serum, and cell suspension were used as solvents to study the photobleaching of ZnPc-F7 in different solutions. Absorbance and fluorescence spectra were measured. Photobleaching kinetics were observed after irradiation for 3–180 min with ZnPc-F7 concentrations of 1–40.00μg/mL. An in vivo imaging system was used to observe the distribution and photobleaching of ZnPc-F7 in mice. ZnPc-F7 was bleached both in vitro and in vivo after exposure to laser energy at 670 nm. ZnPc-F7 was not bleached without irradiation. ‘The type of solvent, irradiation time, and initial concentration influenced the photobleaching rate. Rapid initial phases followed by a slower rate of photobleaching were observed in all four solutions. Fluorescence of ZnPc-F7 in mouse skin was steady and then increased 24 h after injection. There was no significant difference in the extent of fluorescence between normal and psoriasis-like mice. Local administration of ZnPc-F7 showed higher fluorescence intensity in skin at an early time than intravenous injection and lower content in organs after 24 h.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Photobleaching characteristics of α-(8-quinolinoxy) zinc phthalocyanine, a new type of amphipathic complex ; volume:15 ; number:1 ; year:2017 ; pages:400-411 ; extent:12
Open chemistry ; 15, Heft 1 (2017), 400-411 (gesamt 12)
- Creator
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Liu, Han-Qing
Wang, Ying-Ming
Li, Wan-Fang
Li, Chao
Jiang, Zhi-Huan
Bao, Jie
Wei, Jin-Feng
Jin, Hong-Tao
Wang, Ai-Ping
- DOI
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10.1515/chem-2017-0045
- URN
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urn:nbn:de:101:1-2410161559000.313146503885
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:31 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Liu, Han-Qing
- Wang, Ying-Ming
- Li, Wan-Fang
- Li, Chao
- Jiang, Zhi-Huan
- Bao, Jie
- Wei, Jin-Feng
- Jin, Hong-Tao
- Wang, Ai-Ping
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