Caffeine effects on AdoR mRNA expression in Drosophila melanogaster

Abstract: In this study, we aimed to evaluate whether exposure to caffeine in the early stages of development affect AdoR mRNA expression levels in the fruit fly (Drosophila melanogaster) and how this will relate to the developmental success of flies. Adenosine receptors are seen as the most important biochemical targets of caffeine. Simultaneously adenosine signaling orchestrates the development and growth of insects. We demonstrate that AdoR mRNA expression in D. melanogaster is persistent from early stages till imago. Strong alterations in AdoR expression were observed in larvae that had been treated with caffeine. However, after the imaginal molt, the differences in AdoR expression between the insects from all of the test groups evened out despite a wide range of developmental success in the groups. Taken together, these results suggest that caffeine affects the expression of its cellular targets even from the early stages of fruit fly development and thus there is a significantly lower larvae-to-adult survival rate. Moreover, we also proved that the expression of AdoR undergoes a peculiar reset during the maturation of D. melanogaster despite the conditions in which larvae developed.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Caffeine effects on AdoR mRNA expression in Drosophila melanogaster ; volume:11 ; number:1 ; year:2016 ; pages:244-249 ; extent:6 ; Open life sciences ; 11, Heft 1 (2016), 244-249 (gesamt 6)

Contributors, Places and Time

• Creator: Francikowski, Jacek ; Baran, Bartosz ; Płachetka-Bożek, Anna ; Krzyżowski, Michał ; Augustyniak, Maria

Further information

• DOI: 10.1515/biol-2016-0034
• URN: urn:nbn:de:101:1-2409201632160.968964073802
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 15.08.2025, 7:36 AM CEST