Refoldable Foldamers: Global Conformational Switching by Deletion or Insertion of a Single Hydrogen Bond
Abstract: Small changes in the structure of a foldamer may lead to gross changes in conformational preference. We show that the simple insertion or deletion of a single hydrogen bond by changes in pH or by photochemical deprotection is sufficient to refold a helical oligomer, interconverting M and P screw‐sense preference. As a consequence of the switch, information may be transmitted to a remote catalytic site, selectively directing the formation of either of two enantiomeric products by a reaction involving 1,22‐remote intermolecular asymmetric induction.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Refoldable Foldamers: Global Conformational Switching by Deletion or Insertion of a Single Hydrogen Bond ; volume:55 ; number:6 ; year:2016 ; pages:2132-2136 ; extent:5
Angewandte Chemie / International edition. International edition ; 55, Heft 6 (2016), 2132-2136 (gesamt 5)
- Urheber
- DOI
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10.1002/anie.201510605
- URN
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urn:nbn:de:101:1-2022110106132387721789
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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15.08.2025, 07:36 MESZ
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Beteiligte
- Le Bailly, Bryden A. F.
- Byrne, Liam
- Clayden, Jonathan
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